Evaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditions

Basit Öğe Kaydı
dc.authorid0000-0002-0290-1166en_US
dc.contributor.authorBasaran, Nursen
dc.contributor.authorDuydu, Yalcin
dc.contributor.authorUstundag, Aylin
dc.contributor.authorTaner, Gökçe
dc.contributor.authorAydin, Sevtap
dc.contributor.authorAnlar, Hatice Gul
dc.date.accessioned2021-03-20T20:12:34Z
dc.date.available2021-03-20T20:12:34Z
dc.date.issued2019
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.description.abstractIndustrial production and use of boron compounds have increased during the last decades, especially for the manufacture of borosilicate glass, fiberglass, metal alloys and flame retardants. This study was conducted in two districts of Balikesir; Bandirma and Bigadic, which geographically belong to the Marmara Region of Turkey. Bandirma is the production and exportation zone for the produced boric acid and some borates and Bigadic has the largest B deposits in Turkey. 102 male workers who were occupationally exposed to boron from Bandirma and 110 workers who were occupationally and environmentally exposed to boron from Bigadic participated to our study. In this study the DNA damage in the sperm, blood and buccal cells of 212 males was evaluated by comet and micronucleus assays. No significant increase in the DNA damage in blood, sperm and buccal cells was observed in the residents exposed to boron both occupationally and environmentally (p = 0.861) for Comet test in the sperm samples, p = 0.116 for Comet test in the lymphocyte samples, p = 0.042 for micronucleus (MN) test, p = 0.955 for binucleated cells (BN), p = 1.486 for condensed chromatin (CC), p = 0.455 for karyorrhectic cells (KHC), p = 0.541 for karyolitic cells (KLY), p = 1.057 for pyknotic cells (PHC), p = 0.331 for nuclear bud (NBUD)). No correlations were seen between blood boron levels and tail intensity values of the sperm samples, lymphocyte samples, frequencies of MN, BN, KHC, KYL, PHC and NBUD. The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.en_US
dc.description.sponsorshipEti Mine Works General ManagementMinistry of Energy & Natural Resources - Turkeyen_US
dc.description.sponsorshipThe project was funded by Eti Mine Works General Management (2014-2017).en_US
dc.identifier.doi10.1016/j.mrgentox.2018.12.013en_US
dc.identifier.endpage39en_US
dc.identifier.issn1383-5718
dc.identifier.issn1879-3592
dc.identifier.pmid31421736en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage33en_US
dc.identifier.urihttp://doi.org/10.1016/j.mrgentox.2018.12.013
dc.identifier.urihttps://hdl.handle.net/20.500.12885/617
dc.identifier.volume843en_US
dc.identifier.wosWOS:000483453100006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaner, Gökçe
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMutation Research-Genetic Toxicology And Environmental Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBoric aciden_US
dc.subjectBoron exposureen_US
dc.subjectDNA damageen_US
dc.subjectComet assayen_US
dc.titleEvaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditionsen_US
dc.typeArticleen_US

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