Characterization of pomegranate peel extract loaded nanophytosomes and the enhancement of bio-accessibility and storage stability

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dc.authorid0000-0002-6777-273X
dc.authorid0000-0003-2084-7076
dc.authorid0000-0003-0665-8041
dc.authorid0000-0003-2225-7993
dc.authorid0000-0003-1173-5793
dc.contributor.authorDundar, Ayse Neslihan
dc.contributor.authorOzdemir, Sebahat
dc.contributor.authorUzuner, Kubra
dc.contributor.authorParlak, Mahmud Ekrem
dc.contributor.authorSahin, Oya Irmak
dc.contributor.authorDagdelen, Adnan Fatih
dc.contributor.authorSaricaoglu, Furkan Turker
dc.date.accessioned2026-02-12T21:05:21Z
dc.date.available2026-02-12T21:05:21Z
dc.date.issued2023
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractNano-phytosomes are lipid-based nano-carriers and rapidly growing technology for products containing phytochemicals. In this study, pomegranate peel extract (PPE) loaded nanophytosomes (NP) were prepared with phosphatidylcholine (PC) based on thin layer hydration method. The characterization of NP such as entrapment efficiency (EE), particle size, poly-dispersity index (PDI),.-potential and microstructural properties was studied and in vitro bioaccessibility and storage stability of bioactive properties were investigated. The highest EE was determined as 94.99 %, indicating a unique ability as nano-carrier. PPE-loaded NPs showed good characteristics, such as lower PDI values (<0.5), lower particle size (166.70-144.40 nm), and spherical shape of microstructure. All NP complexes showed significant bioaccessibility with TPC, CUPRAC, and ABTS values >50 % in the intestinal medium. The lowest TPC and color difference (.E) during 28 days of storage were found at 4.C, although all NP samples showed better stability at all storage temperatures up to 21 days.
dc.identifier.doi10.1016/j.foodchem.2022.133921
dc.identifier.issn0308-8146
dc.identifier.issn1873-7072
dc.identifier.pmid35969988
dc.identifier.scopus2-s2.0-85135776382
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.foodchem.2022.133921
dc.identifier.urihttps://hdl.handle.net/20.500.12885/6925
dc.identifier.volume398
dc.identifier.wosWOS:000932732700006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofFood Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260212
dc.subjectPomegranate by-products
dc.subjectNanophytosome
dc.subjectIn vitro digestion
dc.subjectNanoencapsulation
dc.titleCharacterization of pomegranate peel extract loaded nanophytosomes and the enhancement of bio-accessibility and storage stability
dc.typeArticle

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