Assessment of DNA damage in ceramic workers

Basit Öğe Kaydı
dc.authorid0000-0002-0290-1166en_US
dc.contributor.authorAnlar, Hatice Gul
dc.contributor.authorTaner, Gökçe
dc.contributor.authorBacanli, Merve
dc.contributor.authorIritas, Servet
dc.contributor.authorKurt, Turker
dc.contributor.authorTutkun, Engin
dc.date.accessioned2021-03-20T20:13:32Z
dc.date.available2021-03-20T20:13:32Z
dc.date.issued2018
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.description.abstractIt is known that ceramic workers are potentially exposed to complex mixture of chemicals such as silica, inorganic lead, lime, beryllium and aluminum that can be associated with an increased risk of several diseases. All operations in the ceramic industries such as mixing, moulding, casting, shaking out and finishing jobs, have been associated with the higher exposure levels and in most of the silica-related industries, average overall exposure exceeded permissible exposure levels for respirable crystalline silica. The aim of this study was to evaluate the possible genotoxic damage in ceramic workers exposed to complex mixture of chemicals mainly crystalline silica. For this purpose, the blood and buccal epithelial cell samples were taken from the ceramic workers (n = 99) and their controls (n = 81). The genotoxicity was assessed by the alkaline comet assay in isolated lymphocytes and whole blood. Micronucleus (MN), binucleated (BN), pyknotic (PYC), condensed chromatin (CC), karyolytic (KYL), karyorrhectic (KHC) and nuclear bud (NBUD) frequencies in buccal epithelial cells and plasma 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) levels were also evaluated. In the study, 38 workers were diagnosed with silicosis, 9 workers were suspected to have silicosis, whereas 52 workers were found to be healthy. DNA damage in blood and lymphocytes; MN, CC + KHC, PYC frequencies in buccal epithelial cells and 8-oxodG levels in plasma were increased in workers compared to their controls. These results showed that occupational chemical mixture exposure in ceramic industry may cause genotoxic damage that can lead to important health problems in the workers.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115S079]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (115S079).en_US
dc.identifier.doi10.1093/mutage/gex016en_US
dc.identifier.endpage104en_US
dc.identifier.issn0267-8357
dc.identifier.issn1464-3804
dc.identifier.issue1en_US
dc.identifier.pmid28992085en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage97en_US
dc.identifier.urihttp://doi.org/10.1093/mutage/gex016
dc.identifier.urihttps://hdl.handle.net/20.500.12885/891
dc.identifier.volume33en_US
dc.identifier.wosWOS:000426079100013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaner, Gökçe
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofMutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleAssessment of DNA damage in ceramic workersen_US
dc.typeArticleen_US

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