T-Shaped Microfluidic Junction Processing of Porous Alginate-Based Films and Their Characteristics

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dc.contributor.authorMutlu, Betül
dc.contributor.authorFarhan, Muhammad
dc.contributor.authorKüçük, İsrafil
dc.date.accessioned2021-03-20T20:12:30Z
dc.date.available2021-03-20T20:12:30Z
dc.date.issued2019
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.description.abstractIn this work, highly monodisperse porous alginate films from bubble bursting were formed on a glass substrate at ambient temperature, by a T-shaped microfluidic junction device method using polyethylene glycol (PEG) stearate and phospholipid as precursors in some cases. Various polymer solution concentrations and feeding liquid flow rates were applied for the generation of monodisperse microbubbles, followed by the conversion of the bubbles to porous film structures on glass substrates. In order to compare the physical properties of polymeric solutions, the effects of alginate, PEG stearate (surfactant), and phospholipid concentrations on the flowability of the liquid in a T-shaped microfluidic junction device were studied. To tailor microbubble diameter and size distribution, a method for controlling the thinning process of the bubbles' shell was also explored. In order to control pore size, shape, and surface as well as internal structure morphologies in the scalable forming of alginate polymeric films, the effect of the feeding liquid's flow rate and concentrations of PEG-stearate and phospholipid was also studied. Digital microscopy images revealed that the as-formed alginate films at the flow rate of 100 mu L.min(-1) and the N-2 gas pressure of 0.8 bar have highly monodisperse microbubbles with a polydispersity index (PDI) of approximately 6.5%. SEM captures also revealed that the as-formed alginate films with high PDI value have similar monodisperse porous surface and internal structure morphologies, with the exception that the as-formed alginate films with the help of phospholipids were mainly formed under our experimental environment. From the Fourier-transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) measurements, we concluded that no chemical composition changes, thermal influence, and crystal structural modifications were observed due to the T-shaped microfluidic junction device technique. The method used in this work could expand and enhance the use of alginate porous films in a wide range of bioengineering applications, especially in tissue engineering and drug delivery, such as studying release behaviors to different internal and surface morphologies.en_US
dc.description.sponsorshipBursa Technical University's BAP [172L03]; Turkey's TUBITAK [118M219]en_US
dc.description.sponsorshipThe authors wish to express their gratitude for the financial support received from the Bursa Technical University's BAP (Grant details, No. 172L03). The authors also thank Turkey's TUBITAK for the partial financial support provided under grant number 118M219. The authors are grateful to Semih Bozkurt (SEM), Mustafa Guler (SEM), Gozde Gecim (Physical property description) and Fuat Kayis (XRD) for technical support in performing characterization tasks. The authors also acknowledge the facility support provided by Bilkent UNAM.en_US
dc.identifier.doi10.3390/polym11091386en_US
dc.identifier.issn2073-4360
dc.identifier.issue9en_US
dc.identifier.pmid31450763en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.3390/polym11091386
dc.identifier.urihttps://hdl.handle.net/20.500.12885/587
dc.identifier.volume11en_US
dc.identifier.wosWOS:000489104300012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMutlu, Betül
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofPolymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectporous filmsen_US
dc.subjectT-shaped microfluidic junctionen_US
dc.subjectcoatingsen_US
dc.subjectbioengineering applicationsen_US
dc.subjectthin filmen_US
dc.titleT-Shaped Microfluidic Junction Processing of Porous Alginate-Based Films and Their Characteristicsen_US
dc.typeArticleen_US

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