Evaluation of oxidative stress levels as biomarkers in vitiligo patients

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dc.contributor.authorİnce, Zeynep
dc.contributor.authorKutlu, Büşra
dc.contributor.authorYılmaz, Nazan
dc.contributor.authorCengiz, Fatma
dc.contributor.authorGüler, Eray
dc.date.accessioned2024-06-24T11:24:03Z
dc.date.available2024-06-24T11:24:03Z
dc.date.issued2023
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümü
dc.description.abstractObjective: Vitiligo is a skin disease that causes the loss of melanocyte cells, which produce pigment in the skin. There is evidence that oxidative stress plays an important role in vitiligo disease of unknown pathogenesis. Evidence suggests that there is increased oxidative stress in melanocytes in patients with vitiligo. The aim of this study is to investigate oxidative stress markers in patients with vitiligo. Materials and Methods: Blood samples were taken from 23 vitiligo patients and 23 healthy control groups without any disease in Bezmialem Vakif University Hospital Dermatology and Venereal Diseases Outpatient Clinic. Total antioxidant levels (TAS) and total oxidant levels (TOS) were measured photometrically method with blood samples. The oxidative stress index (OSI) was calculated as the TOS to TAS level ratio. Results: When the results of the vitiligo patient group were compared with the control group, TOS and OSI were found to be significantly higher than the control group (P < 0.05). No statistically significant result was found in TAS. Conclusions: Our results show that oxidative stress plays a role in the pathogenesis of vitiligo.
dc.identifier.doi10.4103/tjd.tjd_95_23
dc.identifier.endpage135
dc.identifier.issn1308-5255
dc.identifier.issue4
dc.identifier.scopusqualityQ4
dc.identifier.startpage132
dc.identifier.urihttps://hdl.handle.net/20.500.12885/2271
dc.identifier.volume17
dc.identifier.wosWOS:001202169200003
dc.identifier.wosqualityQ4
dc.institutionauthorİnce , Zeynep
dc.language.isoen
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONS
dc.relation.ispartofTURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Öğrenci
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant
dc.subjectoxidant
dc.subjectoxidative stress
dc.subjectvitiligo
dc.titleEvaluation of oxidative stress levels as biomarkers in vitiligo patients
dc.typeArticle

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