Investigating the impact of coagulation bath temperature on the properties of biphasic calcium phosphate/poly(vinylidene fluoride)-based membrane scaffold via immersion precipitation

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dc.authorid0000-0002-0617-8606
dc.authorid0000-0002-6685-5656
dc.contributor.authorMutlu, Buesra
dc.contributor.authorDemirci, Fatma
dc.contributor.authorDuman, Seyma
dc.date.accessioned2026-02-08T15:14:45Z
dc.date.available2026-02-08T15:14:45Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractIn this study, composite membrane scaffolds comprising poly(vinylidene fluoride) (PVDF) and boron-containing biphasic calcium phosphate (BCP) are developed using a non-solvent-induced phase separation technique at coagulation bath temperatures of -5, 0, 10, and 20 degrees C. The morphology, pore size and tensile strength of the scaffolds are primarily influenced by the bath temperature. Moreover, raising the bath temperature enhances the thermal properties and beta-crystalline phase fraction. Results demonstrate that changes in the temperature increase the surface hydrophilicity and reduce the degree of swelling. According to the in vitro bioactivity analysis, apatite growth is affected by the interactive relation between the surface of the samples and the simulated body fluid (SBF) medium, in addition to the superior bioactivity of the scaffolds. In vitro cytotoxicity assay results confirm the extensive spreading of L-929 cells on the sample surfaces, indicating the high biocompatibility of the scaffolds. Based on these favorable properties, the novel composite membranes produced, particularly at 20 degrees C coagulation bath temperature, may contribute to applications in bone tissue engineering. Fabrication of the BCP/PVDF-based membrane scaffold via immersion precipitation. image
dc.description.sponsorshipTUBITAK [124M221]
dc.description.sponsorshipTUBITAK, Grant/Award Number:124M221
dc.identifier.doi10.1002/app.56375
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85206269648
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.56375
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5408
dc.identifier.volume142
dc.identifier.wosWOS:001330532600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectbiological properties
dc.subjectbiphasic calcium phosphate
dc.subjectmechanical properties
dc.subjectmembrane scaffold
dc.subjectpoly(vinylidene fluoride)
dc.titleInvestigating the impact of coagulation bath temperature on the properties of biphasic calcium phosphate/poly(vinylidene fluoride)-based membrane scaffold via immersion precipitation
dc.typeArticle

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