Investigating the impact of coagulation bath temperature on the properties of biphasic calcium phosphate/poly(vinylidene fluoride)-based membrane scaffold via immersion precipitation
Küçük Resim Yok
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, composite membrane scaffolds comprising poly(vinylidene fluoride) (PVDF) and boron-containing biphasic calcium phosphate (BCP) are developed using a non-solvent-induced phase separation technique at coagulation bath temperatures of -5, 0, 10, and 20 degrees C. The morphology, pore size and tensile strength of the scaffolds are primarily influenced by the bath temperature. Moreover, raising the bath temperature enhances the thermal properties and beta-crystalline phase fraction. Results demonstrate that changes in the temperature increase the surface hydrophilicity and reduce the degree of swelling. According to the in vitro bioactivity analysis, apatite growth is affected by the interactive relation between the surface of the samples and the simulated body fluid (SBF) medium, in addition to the superior bioactivity of the scaffolds. In vitro cytotoxicity assay results confirm the extensive spreading of L-929 cells on the sample surfaces, indicating the high biocompatibility of the scaffolds. Based on these favorable properties, the novel composite membranes produced, particularly at 20 degrees C coagulation bath temperature, may contribute to applications in bone tissue engineering. Fabrication of the BCP/PVDF-based membrane scaffold via immersion precipitation. image
Açıklama
Anahtar Kelimeler
biological properties, biphasic calcium phosphate, mechanical properties, membrane scaffold, poly(vinylidene fluoride)
Kaynak
Journal of Applied Polymer Science
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
142
Sayı
3
