Enhanced antibacterial and genoprotective properties of nanoliposomal Satureja hortensis L. essential oil

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dc.authorid0000-0002-0290-1166
dc.authorid0000-0002-4449-5290
dc.authorid0000-0002-1786-1216
dc.contributor.authorCagal, Munevver Muge
dc.contributor.authorTaner, Gokce
dc.contributor.authorKalayci, Sadik
dc.contributor.authorDuman, Gulengul
dc.date.accessioned2026-02-08T15:15:31Z
dc.date.available2026-02-08T15:15:31Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractNanoliposomes are drug delivery systems that improve bioavailability by encapsulating therapeutic agents. The main objective of this study was to investigate the effects of nanoliposomal (NL) formulation on enhancing the bioavailability of essential oil. The essential oil of Satureja hortensis (SHO) was encapsulated in nanoliposomes (SHNLs). Physicochemical characterizations of NL formulations (size, charge, polydispersity index [PDI]) were evaluated by dynamic light scattering technique. The nanoliposome encapsulation efficiency (EE) was calculated as 89.90%. The prepared bionanosystems demonstrated significant antibacterial activities against Escherichia coli ATCC 10536, Pseudomonas aeruginosa ATCC 15442, and Staphylococcus aureus ATCC as determined by the agar diffusion method and microdilution tests. Minimum inhibitory concentration (MIC) values for SHNLs were found to be 5.187 mu g/mu L for E. coli and 2.59 mu g/mu L for both P. aeruginosa and S. aureus. Importantly, despite the lower substance content, both SHNLs and SHO exhibited comparable antibacterial activity against all tested strains. Furthermore, in order to determine the toxicity profile and possible effects on DNA damage or repair both the genotoxic and antigenotoxic effects of SHNLs were assessed using the cytokinesis-blocked micronucleus (CBMN) method in human lymphocyte cultures. The experimental data collectively indicate that the NL formulation of the S. hortensis essential oil enhances antibacterial activities and provides genoprotective effects against DNA damage. This highlights the significance of liposomal formulations of antioxidants in augmenting their biological activity. The results indicate that SHNLs can be a safe antibacterial agent for the pharmaceutical industry.
dc.description.sponsorshipScientific Research Projects Units of Bursa technical University [171N05]
dc.description.sponsorshipThis work was funded by the scientific Research Projects Units of Bursa technical University (grant number 171N05).
dc.identifier.doi10.1080/01480545.2024.2362180
dc.identifier.endpage186
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue1
dc.identifier.pmid38835158
dc.identifier.scopus2-s2.0-85195210234
dc.identifier.scopusqualityQ1
dc.identifier.startpage180
dc.identifier.urihttps://doi.org/10.1080/01480545.2024.2362180
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5828
dc.identifier.volume48
dc.identifier.wosWOS:001243497300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectNanoliposomal formulation
dc.subjectSatureja hortensis
dc.subjectgenotoxicity
dc.subjectmicronucleus assay
dc.subjectsummer savory
dc.titleEnhanced antibacterial and genoprotective properties of nanoliposomal Satureja hortensis L. essential oil
dc.typeArticle

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