The stability and fragility of biological networks: eukaryotic model organism Saccharomyces cerevisiae

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dc.authorid0000-0003-3144-8724en_US
dc.contributor.authorAltuntaş, Volkan
dc.contributor.authorGok, Murat
dc.date.accessioned2021-03-20T20:14:02Z
dc.date.available2021-03-20T20:14:02Z
dc.date.issued2017
dc.departmentBTÜ, Rektörlüğe Bağlı Birimler, Bilgi İşlem Daire Başkanlığıen_US
dc.description2017 International Conference on Computer Science and Engineering (UBMK) -- OCT 05-08, 2017 -- Antalya, TURKEYen_US
dc.description.abstractRecent studies of biological networks show that these networks arc robust against the random or selective deletion of network nodes and I or edges. Ability to maintain performance of network under mutations is a key feature of live systems that has long been recognized. However, the molecular and cellular basis of this stability has just begun to be understood. Robustness is a key to understanding cellular complexity, illuminating design principles, and encouraging closer interaction between experiment and theory. A biological network mutation can be defined as the creation of a new network with k allowed network change operations for a given G network. While mutating the network, our goal is to observe the change in the measured distance estimate value after k changes of the defined distance measurement method M. In this study, the effects of edge deletion and edge insertion mutations on network topology and diffusion-based function estimation algorithms are investigated by using random mutation model on the protein-protein interaction network of eukaryote Saccharomyces cerevisiae yeast, containing 5936 nodes and 65139 edges. Experimental results shows that Saccharomyces cerevisiae protein-protein interaction network has high robustness against random mutations and that the generated mutations have no significant effect on network topology and estimation techniques.en_US
dc.description.sponsorshipIEEE Adv Technol Human, Istanbul Teknik Univ, Gazi Univ, Atilim Univ, TBV, Akdeniz Univ, Tmmob Bilgisayar Muhendisleri Odasien_US
dc.identifier.endpage118en_US
dc.identifier.isbn978-1-5386-0930-9
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12885/986
dc.identifier.wosWOS:000426856900022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAltuntaş, Volkan
dc.language.isotren_US
dc.publisherIeeeen_US
dc.relation.ispartof2017 International Conference On Computer Science And Engineering (Ubmk)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiological networksen_US
dc.subjectsaccharomyces cerevisiaeen_US
dc.subjectnetwork mutationsen_US
dc.titleThe stability and fragility of biological networks: eukaryotic model organism Saccharomyces cerevisiaeen_US
dc.typeConference Objecten_US

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