The stability and fragility of biological networks: eukaryotic model organism Saccharomyces cerevisiae
Küçük Resim Yok
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ieee
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Recent studies of biological networks show that these networks arc robust against the random or selective deletion of network nodes and I or edges. Ability to maintain performance of network under mutations is a key feature of live systems that has long been recognized. However, the molecular and cellular basis of this stability has just begun to be understood. Robustness is a key to understanding cellular complexity, illuminating design principles, and encouraging closer interaction between experiment and theory. A biological network mutation can be defined as the creation of a new network with k allowed network change operations for a given G network. While mutating the network, our goal is to observe the change in the measured distance estimate value after k changes of the defined distance measurement method M. In this study, the effects of edge deletion and edge insertion mutations on network topology and diffusion-based function estimation algorithms are investigated by using random mutation model on the protein-protein interaction network of eukaryote Saccharomyces cerevisiae yeast, containing 5936 nodes and 65139 edges. Experimental results shows that Saccharomyces cerevisiae protein-protein interaction network has high robustness against random mutations and that the generated mutations have no significant effect on network topology and estimation techniques.
Açıklama
2017 International Conference on Computer Science and Engineering (UBMK) -- OCT 05-08, 2017 -- Antalya, TURKEY
Anahtar Kelimeler
biological networks, saccharomyces cerevisiae, network mutations
Kaynak
2017 International Conference On Computer Science And Engineering (Ubmk)
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
