Evaluation of mechanical behavior, bioactivity, and cytotoxicity of chitosan/akermanite-TiO2 3D-printed scaffolds for bone tissue applications

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dc.authorid0000-0002-9946-6729en_US
dc.authorid0000-0002-6685-5656en_US
dc.contributor.authorBulut, Büşra
dc.contributor.authorDuman, Şeyma
dc.date.accessioned2022-10-12T07:46:01Z
dc.date.available2022-10-12T07:46:01Z
dc.date.issued2022en_US
dc.departmentBTÜen_US
dc.description.abstractThis report aimed to evaluate the mechanical behavior, bioactivity, and cytotoxicity of novel chitosan/akermanite-TiO2 (CS/AK/Ti) composite scaffolds fabricated using the 3D-printing method. The morphological and structural properties of these scaffolds were characterized by Fourier transform spectroscopy (FTIR) and scanning electron microscopy (SEM). The mechanical behavior was examined by measuring the compressive strength, while the bioactivity was estimated in the simulated body fluid (SBF), and also the cytotoxicity of the scaffolds was assessed by conducting cell culturing experiments in vitro. It was found that the mechanical properties were considerably affected by the amount of TiO2. The scaffolds had the possessed bone-like apatite forming ability, which indicated high bioactivity. Furthermore, L929 cells spread well on the surface, proliferated, and had good viability regarding the cell behaviors. The outcomes confirmed that the morphological, biological, and mechanical properties of developed 3D-composite scaffolds nearly mimicked the features of natural bone tissue. In summary, these findings showed that the 3D-printed scaffolds with an interconnected pore structure and improved mechanical properties were a potential candidate for bone tissue applications.en_US
dc.identifier.doi10.1016/j.ceramint.2022.04.104en_US
dc.identifier.issn0272-8842
dc.identifier.issn1873-3956
dc.identifier.issue15en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12885/2064
dc.identifier.volume48en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorBulut, Büşra
dc.institutionauthorDuman, Şeyma
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofCERAMICS INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTiO2en_US
dc.subjectAkermaniteen_US
dc.subject3D printingen_US
dc.subjectMechanical propertiesen_US
dc.subjectBone tissue applicationsen_US
dc.titleEvaluation of mechanical behavior, bioactivity, and cytotoxicity of chitosan/akermanite-TiO2 3D-printed scaffolds for bone tissue applicationsen_US
dc.typeArticleen_US

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