Design and Characterization of Polyvinyl Alcohol/Kappa-Carrageenan Pickering Emulsion Biocomposite Films for Potential Wound Care Applications
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aimed to develop polyvinyl alcohol (PVA) and kappa-carrageenan (kappa CA) biocomposite films using a Pickering emulsion technique for wound care applications. Juniper essential oil and modified sepiolite were incorporated to enhance functionality, with films prepared via solvent casting and characterized for structural, thermal, and mechanical properties. The PCOS-2 film exhibited the highest mechanical performance, with Young's modulus of 6.25 +/- 1.3 MPa, tensile strength of 5.65 +/- 1.7 MPa, and elongation at break of 608.96% +/- 72.8%. Antibacterial assays showed inhibition zones of 9 and 10 mm against Staphylococcus aureus and Escherichia coli, respectively, for the PCOS-2 film, while antioxidant activity reached 63% DPPH radical scavenging after 12 h. Additionally, porosity and hydrophilicity were enhanced, as indicated by contact angles of 55 degrees for the control film and 71.2 degrees for PCOS-2. These results underscore the potential of PVA/kappa CA biocomposite films as sustainable and bioactive wound dressings, combining mechanical resilience, bioactivity, and environmental compatibility, with future efforts focused on optimizing antibacterial efficacy against gram-negative bacteria and clinical validation.
Açıklama
Anahtar Kelimeler
anti-bacterial efficiency, biocomposite film, juniper essential oil, modified sepiolite, PVA/carrageenan
Kaynak
Journal of Biomedical Materials Research Part A
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
113
Sayı
1
