Fabrication and characterization of electrospun folic acid/hybrid fibers: In vitro controlled release study and cytocompatibility assays

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dc.authorid0000-0003-2048-2951en_US
dc.authorid0000-0002-1640-6035en_US
dc.authorscopusid57194680814en_US
dc.authorscopusid30767899000en_US
dc.contributor.authorParın, Fatma Nur
dc.contributor.authorUllah S.
dc.contributor.authorYıldırım, Kenan
dc.contributor.authorHashmi M.
dc.contributor.authorKim I.-S.
dc.date.accessioned2022-04-01T08:36:55Z
dc.date.available2022-04-01T08:36:55Z
dc.date.issued2021en_US
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Polimer Malzeme Mühendisliği Bölümüen_US
dc.description.abstractThe fabrication of skin-care products with therapeutic properties has been significant for human health trends. In this study, we developed efficient hydrophilic composite nanofibers (NFs) loaded with the folic acid (FA) by electrospinning and electrospraying processes for tissue engineering or wound healing cosmetic applications. The morphological, chemical and thermal characteristics, in vitro release properties, and cytocompatibility of the resulting composite fibers with the same amount of folic acid were analyzed. The SEM micrographs indicate that the obtained nanofibers were in the nanometer range, with an average fiber diameter of 75–270 nm and a good porosity ratio (34–55%). The TGA curves show that FA inhibits the degradation of the polymer and acts as an antioxidant at high temperatures. More physical interaction between FA and matrices has been shown to occur in the electrospray process than in the electrospinning process. A UV-Vis in vitro study of FA-loaded electrospun fibers for 8 h in artificial acidic (pH 5.44) and alkaline (pH 8.04) sweat solutions exhibited a rapid release of FA-loaded electrospun fibers, showing the effect of polymer matrix–FA interactions and fabrication processes on their release from the nanofibers. PVA-CHi/FA webs have the highest release value, with 95.2% in alkaline media. In acidic media, the highest release (92%) occurred on the PVA-Gel–CHi/sFA sample, and this followed first-order and Korsmeyer–Peppas kinetic models. Further, the L929 cytocompatibility assay results pointed out that all NFs (with/without FA) generated had no cell toxicity; on the contrary, the FA in the fibers facilitates cell growth. Therefore, the nanofibers are a potential candidate material in skin-care and tissue engineering applications.en_US
dc.identifier.doi10.3390/polym13203594en_US
dc.identifier.issn20734360
dc.identifier.issue20en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12885/1830
dc.identifier.volume13en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorParın, Fatma Nur
dc.institutionauthorYıldırım, Kenan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPolymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectDrug releaseen_US
dc.subjectFolic aciden_US
dc.subjectHybrid nanofiberen_US
dc.subjectIn vitro studyen_US
dc.titleFabrication and characterization of electrospun folic acid/hybrid fibers: In vitro controlled release study and cytocompatibility assaysen_US
dc.typeArticleen_US

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