Comparative neuroprotective effects of royal jelly and its unique compound 10-hydroxy-2-decenoic acid on ischemia-induced inflammatory, apoptotic, epigenetic and genotoxic changes in a rat model of ischemic stroke

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dc.authorid0000-0001-6814-0585
dc.authorid0000-0002-6097-5585
dc.contributor.authorKoc, Cansu
dc.contributor.authorAydemir, Cigdem Inci
dc.contributor.authorSalman, Berna
dc.contributor.authorCakir, Aysen
dc.contributor.authorAkbulut, Nursel Hasanoglu
dc.contributor.authorKarabarut, Pinar Levent
dc.contributor.authorCansev, Mehmet
dc.date.accessioned2026-02-08T15:15:33Z
dc.date.available2026-02-08T15:15:33Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractObjectivesThis study aimed to compare the efficacy of royal jelly (RJ) and its major fatty acid 10-hydroxy-2-decenoic acid (10-HDA) on ischemic stroke-related pathologies using histological and molecular approaches.MethodsMale rats were subjected to middle cerebral artery occlusion (MCAo) to induce ischemic stroke and were supplemented daily with either vehicle (control group), RJ or 10-HDA for 7 days starting on the day of surgery. On the eighth day, rats were sacrificed and brain tissue and blood samples were obtained to analyze brain infarct volume, DNA damage as well as apoptotic, inflammatory and epigenetic parameters.ResultsBoth RJ and 10-HDA supplementation significantly reduced brain infarction and decreased weight loss when compared to control animals. These effects were associated with reduced levels of active caspase-3 and PARP-1 and increased levels of acetyl-histone H3 and H4. Although both RJ and 10-HDA treatments significantly increased acetyl-histone H3 levels, the effect of RJ was more potent than that of 10-HDA. RJ and 10-HDA supplementation also alleviated DNA damage by significantly reducing tail length, tail intensity and tail moment in brain tissue and peripheral lymphocytes, except for the RJ treatment which tended to reduce tail moment in lymphocytes without statistical significance.ConclusionsOur findings suggest that neuroprotective effects of RJ in experimental stroke can mostly be attributed to 10-HDA.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK) [118S391]
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkiye (TUBITAK) [grant number 118S391].
dc.identifier.doi10.1080/1028415X.2024.2344141
dc.identifier.endpage49
dc.identifier.issn1028-415X
dc.identifier.issn1476-8305
dc.identifier.issue1
dc.identifier.pmid38657030
dc.identifier.scopus2-s2.0-85191345167
dc.identifier.scopusqualityQ1
dc.identifier.startpage37
dc.identifier.urihttps://doi.org/10.1080/1028415X.2024.2344141
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5845
dc.identifier.volume28
dc.identifier.wosWOS:001207956900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNutritional Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectMiddle cerebral artery occlusion
dc.subjectischemic stroke
dc.subjectroyal jelly
dc.subject10-hydroxy-2-decenoic acid
dc.subjectneuroprotection
dc.subjectcomet
dc.subjectinflammation
dc.subjectapoptosis
dc.titleComparative neuroprotective effects of royal jelly and its unique compound 10-hydroxy-2-decenoic acid on ischemia-induced inflammatory, apoptotic, epigenetic and genotoxic changes in a rat model of ischemic stroke
dc.typeArticle

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