Nanoliposomal system for augmented antibacterial and antiproliferative efficacy of Melissa officinalis L. extract

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dc.authorid0000-0002-7296-5050
dc.authorid0000-0002-0290-1166
dc.authorid0000-0002-1786-1216
dc.contributor.authorNizam, Nagihan
dc.contributor.authorTaner, Gokce
dc.contributor.authorCagal, Munevver Muge
dc.date.accessioned2026-02-08T15:15:40Z
dc.date.available2026-02-08T15:15:40Z
dc.date.issued2024
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractObjective This study focused on the nanoliposomal encapsulation of bioactive compounds extracted from Melissa officinalis L. (ME) using ethanol as a strategy to improve the antibacterial activity, anticytotoxic, and antiproliferative properties.Methods Nanoliposomes loaded with ME (MEL) were characterized for total phenolic content, particle size, polydispersity, and encapsulation efficiency. The minimum inhibitory concentration (MIC) values for MEL and ME were determined to evaluate antibacterial activity. To examine the toxicity profiles of ME and MEL, tests were conducted on the A549 and BEAS-2B cell lines using the MTT assay. Furthermore, an in vitro sctrach assay was conducted to evaluate the antiproliferative effects of ME and MEL on A549 cells.Results Nanoliposomes presented entrapment efficiency higher than 80%, nanometric particle size, and narrow polydispersity. The MIC values for MEL and ME were observed as 93.75 mu g/mu L against E. coli. MIC values for MEL and ME were achieved as 4.68 mu g/mu L and 9.375 mu g/mL against S. aureus, respectively. The IC50 values for ME were determined to be 1.13 mg/mL and 0.806 mg/mL, while the IC50 values for MEL were found to be 3.5 mg/mL and 0.868 mg/mL on A549 and BEAS-2B cell lines, respectively. Additionally, The MEL showed an antiproliferative effect against A549 cells at 500 mu g/mL concentration.Conclusion All experimental findings unequivocally demonstrate that the novel nanoliposomal system has effectively augmented the antibacterial activities and antiproliferative effects of ME. The initial findings indicate that nanoliposomes could effectively serve as carriers for ME in pharmaceutical applications.
dc.description.sponsorshipScientific Research Projects Units of Bursa Technical University [190Y19]
dc.description.sponsorshipThis work was funded by the Scientific Research Projects Units of Bursa Technical University (grant number 190Y19).
dc.identifier.doi10.1093/toxres/tfae198
dc.identifier.issn2045-452X
dc.identifier.issn2045-4538
dc.identifier.issue6
dc.identifier.pmid39677494
dc.identifier.scopus2-s2.0-85212323485
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1093/toxres/tfae198
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5877
dc.identifier.volume13
dc.identifier.wosWOS:001377092600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofToxicology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectLemon balm
dc.subjectNanoliposome
dc.subjectAntiproliferative
dc.subjectCytotoxic
dc.subjectAntibacterial
dc.titleNanoliposomal system for augmented antibacterial and antiproliferative efficacy of Melissa officinalis L. extract
dc.typeArticle

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