Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release.

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dc.contributor.authorErcelik, Melis
dc.contributor.authorTekin, Cagla
dc.contributor.authorParın, Fatma Nur
dc.contributor.authorMutlu, Büşra
dc.contributor.authorDoğan, Hazal Yılmaz
dc.contributor.authorTezcan, Gulcin
dc.contributor.authorAksoy, Secil Ak
dc.contributor.authorGurbuz, Melisa
dc.contributor.authorYıldırım, Kenan
dc.contributor.authorBekar, Ahmet
dc.contributor.authorKocaeli, Hasan
dc.contributor.authorTaskapilioglu, Mevlut Ozgur
dc.contributor.authorEser, Pinar
dc.contributor.authorTunca, Berrin
dc.date.accessioned2024-06-06T12:48:29Z
dc.date.available2024-06-06T12:48:29Z
dc.date.issued2023
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.description.abstractGlioblastoma (GB) has susceptibility to post-surgical recurrence. Therefore, local treatment methods are required against recurrent GB cells in the post-surgical area. In this study, we developed a nanofiber-based local therapy against GB cells using Oleuropein (OL), and rutin and their combinations with Temozolomide (TMZ). The polylactic acid (PLA) core-shell nanofiber webs were encapsulated with OL (PLA), rutin (PLA), and TMZ (PLA) by an electrospinning process. A SEM visualized the morphology and the total immersion method determined the release characteristics of PLA webs. Real-time cell tracking analysis for cell growth, dual Acridine Orange/Propidium Iodide staining for cell viability, a scratch wound healing assay for migration capacity, and a sphere formation assay for tumor spheroid aggressiveness were used. All polymeric nanofiber webs had core-shell structures with an average diameter between 133 ± 30.7-139 ± 20.5 nm. All PLA webs promoted apoptotic cell death, suppressed cell migration, and spheres growth (p < 0.0001). PLA and PLA suppressed GB cell viability with a controlled release that increased over 120 h, while PLA caused rapid cell inhibition (p < 0.0001). Collectively, our findings suggest that core-shell nano-webs could be a novel and effective therapeutic tool for the controlled release of OL and TMZ against recurrent GB cells.
dc.identifier.citationErcelik M, Tekin C, Parin FN, Mutlu B, Dogan HY, Tezcan G, Aksoy SA, Gurbuz M, Yildirim K, Bekar A, Kocaeli H, Taskapilioglu MO, Eser P, Tunca B. Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release. Int J Biol Macromol. 2023 Dec 31;253(Pt 2):126722. doi: 10.1016/j.ijbiomac.2023.126722. Epub 2023 Sep 8. PMID: 37673167.
dc.identifier.doihttps://doi.org/10.1016/j.ijbiomac.2023.126722
dc.identifier.issn01418130
dc.identifier.pmid37673167
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12885/2240
dc.identifier.volume253
dc.identifier.wosWOS:001077751100001
dc.identifier.wosqualityQ1
dc.institutionauthorParın, Fatma Nur
dc.institutionauthorYıldırım, Kenan
dc.institutionauthorMutlu, Büşra
dc.institutionauthorDoğan, Hazal Yılmaz
dc.institutionauthoridhttps://orcid.org/0000-0003-2048-2951
dc.institutionauthoridhttps://orcid.org/0000-0002-1640-6035
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitak121S624
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCombined treatment
dc.subjectGlioblastoma local treatment
dc.subjectNano-based drug delivery systems
dc.titleCo-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release.
dc.typeArticle

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