Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release.
dc.contributor.author | Ercelik, Melis | |
dc.contributor.author | Tekin, Cagla | |
dc.contributor.author | Parın, Fatma Nur | |
dc.contributor.author | Mutlu, Büşra | |
dc.contributor.author | Dogan, Hazal Yilmaz | |
dc.contributor.author | Tezcan, Gulcin | |
dc.contributor.author | Aksoy, Secil Ak | |
dc.contributor.author | Gurbuz, Melisa | |
dc.contributor.author | Yıldırım, Kenan | |
dc.contributor.author | Bekar, Ahmet | |
dc.contributor.author | Kocaeli, Hasan | |
dc.contributor.author | Taskapilioglu, Mevlut Ozgur | |
dc.contributor.author | Eser, Pinar | |
dc.contributor.author | Tunca, Berrin | |
dc.date.accessioned | 2024-06-06T12:48:29Z | |
dc.date.available | 2024-06-06T12:48:29Z | |
dc.date.issued | 2023-12-31 | |
dc.department | BTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Polimer Malzeme Mühendisliği Bölümü | |
dc.description.abstract | Glioblastoma (GB) has susceptibility to post-surgical recurrence. Therefore, local treatment methods are required against recurrent GB cells in the post-surgical area. In this study, we developed a nanofiber-based local therapy against GB cells using Oleuropein (OL), and rutin and their combinations with Temozolomide (TMZ). The polylactic acid (PLA) core-shell nanofiber webs were encapsulated with OL (PLA), rutin (PLA), and TMZ (PLA) by an electrospinning process. A SEM visualized the morphology and the total immersion method determined the release characteristics of PLA webs. Real-time cell tracking analysis for cell growth, dual Acridine Orange/Propidium Iodide staining for cell viability, a scratch wound healing assay for migration capacity, and a sphere formation assay for tumor spheroid aggressiveness were used. All polymeric nanofiber webs had core-shell structures with an average diameter between 133 ± 30.7-139 ± 20.5 nm. All PLA webs promoted apoptotic cell death, suppressed cell migration, and spheres growth (p < 0.0001). PLA and PLA suppressed GB cell viability with a controlled release that increased over 120 h, while PLA caused rapid cell inhibition (p < 0.0001). Collectively, our findings suggest that core-shell nano-webs could be a novel and effective therapeutic tool for the controlled release of OL and TMZ against recurrent GB cells. | |
dc.identifier.citation | Ercelik M, Tekin C, Parin FN, Mutlu B, Dogan HY, Tezcan G, Aksoy SA, Gurbuz M, Yildirim K, Bekar A, Kocaeli H, Taskapilioglu MO, Eser P, Tunca B. Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release. Int J Biol Macromol. 2023 Dec 31;253(Pt 2):126722. doi: 10.1016/j.ijbiomac.2023.126722. Epub 2023 Sep 8. PMID: 37673167. | |
dc.identifier.doi | https://doi.org/10.1016/j.ijbiomac.2023.126722 | |
dc.identifier.issn | 01418130 | |
dc.identifier.pmid | 37673167 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12885/2240 | |
dc.identifier.volume | 253 | |
dc.identifier.wos | WOS:001077751100001 | |
dc.identifier.wosquality | Q1 | |
dc.institutionauthor | Parın,, Fatma Nur | |
dc.institutionauthor | Yıldırım, Kenan | |
dc.institutionauthor | Mutlu, Büşra | |
dc.institutionauthorid | https://orcid.org/0000-0003-2048-2951 | |
dc.institutionauthorid | https://orcid.org/0000-0002-1640-6035 | |
dc.language.iso | en | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | International Journal of Biological Macromolecules | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.relation.tubitak | 121S624 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Combined treatment | |
dc.subject | Glioblastoma local treatment | |
dc.subject | Nano-based drug delivery systems | |
dc.title | Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release. | |
dc.type | Article |
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