Encapsulation of antioxidant beta-carotene by cyclodextrin complex electrospun nanofibers: Solubilization and stabilization of beta-carotene by cyclodextrins

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dc.authorid0000-0002-9011-4495
dc.authorid0000-0001-6220-6504
dc.authorid0000-0003-1814-5104
dc.contributor.authorYildiz, Zehra Irem
dc.contributor.authorTopuz, Fuat
dc.contributor.authorKilic, Mehmet Emin
dc.contributor.authorDurgun, Engin
dc.contributor.authorUyar, Tamer
dc.date.accessioned2026-02-12T21:05:05Z
dc.date.available2026-02-12T21:05:05Z
dc.date.issued2023
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractCarotenoids act as effective antioxidant defense systems in humans as they scavenge molecular oxygen and peroxyl radicals. However, their poor water solubility and being susceptible to degradation driven by light and oxygen hinder their bioactivity, therefore, they should be stabilized by host matrices against oxidation. Here, beta-carotene was encapsulated in electrospun cyclodextrin (CD) nanofibers to increase its water-solubility and photostability to enhance its antioxidant bioactivity. beta-carotene/CD complex aqueous solutions were electrospun into nanofibers. The bead-free morphology of the beta-carotene/CD nanofibers was confirmed by SEM. The formation of beta-carotene/CD complexes was explored through computational modeling and experimentally by FTIR, XRD and solubility tests. The antioxidant activity of the fibers exposed to UV irradiation was demonstrated via a free radical scavenger assay, where beta-carotene/CD nanofibers revealed protection against UV radiation. Overall, this work reports the water-borne electrospinning of antioxidant beta-carotene/CD inclusion complex nanofibers, which stabilize the encapsulated beta-carotene against UV-mediated oxidation.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [117Z535]; TUBITAK-BIDEB; Science Academy (Turkey); Istanbul Technical University
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK, project#117Z535, 2515 COST Program) is acknowledged for funding the research. Z. I. Yildiz thanks to TUBITAK-BIDEB for the PhD scholarship. F. Topuz acknowledges the BAGEP Award from Science Academy (Turkey) and the Young Researcher Award from Istanbul Technical University.
dc.identifier.doi10.1016/j.foodchem.2023.136284
dc.identifier.issn0308-8146
dc.identifier.issn1873-7072
dc.identifier.pmid37156137
dc.identifier.scopus2-s2.0-85158023553
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.foodchem.2023.136284
dc.identifier.urihttps://hdl.handle.net/20.500.12885/6776
dc.identifier.volume423
dc.identifier.wosWOS:001001759400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofFood Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260212
dc.subjectbeta-carotene
dc.subjectCyclodextrin
dc.subjectInclusion complex
dc.subjectNanofibers
dc.subjectElectrospinning
dc.subjectAntioxidant
dc.titleEncapsulation of antioxidant beta-carotene by cyclodextrin complex electrospun nanofibers: Solubilization and stabilization of beta-carotene by cyclodextrins
dc.typeArticle

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