Improved transdermal delivery of cetirizine hydrochloride using polymeric microneedles

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dc.authorid0000-0002-1284-8880en_US
dc.contributor.authorArshad, Muhammad Sohail
dc.contributor.authorHassan, Sana
dc.contributor.authorHussain, Amjad
dc.contributor.authorAbbas, Nasir
dc.contributor.authorKüçük, İsrafil
dc.contributor.authorNazari, Kazem
dc.date.accessioned2021-03-20T20:12:27Z
dc.date.available2021-03-20T20:12:27Z
dc.date.issued2019
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Metalurji ve Malzeme Mühendisliği Bölümüen_US
dc.description.abstractPurpose The aim of this study was to design and characterize microneedle patch formulation containing cetirizine hydrochloride. Methods Chitosan was co-formulated with cetirizine hydrochloride. Transdermal patches were prepared by casting this solution to microneedle molds. Control patches were formulated by casting this solution to a plain cuvet of same area as mold but lacking microneedles. An array of methods namely; differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) were employed for the characterization of the films and the microneedles accordingly whereas in vitro permeation studies were conducted across rat skin. Light microscopy was performed to assess any histological changes upon microneedles application onto the rat skin. Results The patches had a reproducible thickness (0.86 +/- 0.06 mm) and folding endurance. Both the blank and drug loaded patches had 100 microneedles each of 300 micrometre length. In addition, the microneedle patches were ascribed with a two-fold increase in drug permeation across rat skin in the presence of microneedles as compared to the control formulations. Histological examination confirms a minimal invasion of the skin conferred by the microneedles. Conclusion The microneedle patches serve as an alternate route of drug administration in patients with nausea and swelling difficulties. Graphical abstract Microneedle patch manifest a two-fold increase in the skin permeation of Cetirizine Hydrochloride as compared to the control that is drug loaded patch without microneedlesen_US
dc.description.sponsorshipHigher Education Commision of Pakistan under National Research Program for Universities (NRPU) [7401/Punjab/NRPU/RD/HEC/2017]en_US
dc.description.sponsorshipThe authors acknowledge the financial support provided by Higher Education Commision of Pakistan under National Research Program for Universities (NRPU) vide No: 7401/Punjab/NRPU/R&D/HEC/2017.en_US
dc.identifier.doi10.1007/s40199-019-00301-3en_US
dc.identifier.endpage681en_US
dc.identifier.issn2008-2231
dc.identifier.issue2en_US
dc.identifier.pmid31630328en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage673en_US
dc.identifier.urihttp://doi.org/10.1007/s40199-019-00301-3
dc.identifier.urihttps://hdl.handle.net/20.500.12885/565
dc.identifier.volume27en_US
dc.identifier.wosWOS:000491667500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKüçük, İsrafil
dc.language.isoenen_US
dc.publisherSpringer International Publishing Agen_US
dc.relation.ispartofDaru-Journal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMicroneedlesen_US
dc.subjectTransdermal Drug deliveryen_US
dc.subjectCetirizine Hydrochlorideen_US
dc.titleImproved transdermal delivery of cetirizine hydrochloride using polymeric microneedlesen_US
dc.typeArticleen_US

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