Nanoliposomal juglone/?-cyclodextrin complex as a biocontrol strategy against plant pathogenic bacteria

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dc.contributor.authorBezir, Kubra
dc.contributor.authorHoruz, Sumer
dc.contributor.authorAcar, Serap
dc.contributor.authorCagal, Munevver Muge
dc.date.accessioned2026-02-08T15:15:32Z
dc.date.available2026-02-08T15:15:32Z
dc.date.issued2026
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractTomatoes are susceptible to a variety of pathogens, including bacteria, which can significantly impact plant yield and quality. The application of natural antibacterial agents, such as juglone, has shown promise in the biocontrol of these pathogens. The main objective of this study was to investigate the effects of liposomal encapsulation on enhancing the bioavailability of juglone as a biocontrol agent. The entrapment of juglone in nanoliposomes as water-soluble cyclodextrin complexes represents a novel strategy that merges the distinct advantages of these two systems into one. In this study, the juglone/beta-cyclodextrin inclusion complex was successfully encapsulated in nanoliposomes (J/beta-CD/L). Physicochemical and morphological characterizations of the formulations were conducted. The release of juglone from liposomes exhibited a cumulative release of 46.73% at 72 hours. The MIC values of the J/beta-CD/L molecule against plant pathogenic bacteria Pseudomonas syringae pv. tomato strain SH-1 (Pst), Xanthomonas euvesicatoria strain SH-2 (Xeu), and Clavibacter michiganensis subsp. michiganensis strain SH-3 (Cmm) were 68.93 mu g/mL, 34.47 mu g/mL, and 68.93 mu g/mL, respectively. These MIC values were found to be lower than free juglone. Based on the seed germination results, the prepared formulation did not show any phytotoxic effect on tomato seeds at the applied concentrations. Thus, the nanoliposomal encapsulation technique appears to be a promising method for enhancing the antibacterial effectiveness of juglone as a biocontrol agent.
dc.description.sponsorshipBursa Technical University Scientific Research [230Y005]
dc.description.sponsorshipThis work was supported by the Bursa Technical University Scientific Research Projects Coordinatorship under project number 230Y005.
dc.identifier.doi10.1080/08982104.2026.2618757
dc.identifier.issn0898-2104
dc.identifier.issn1532-2394
dc.identifier.pmid41572741
dc.identifier.scopus2-s2.0-105028389850
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1080/08982104.2026.2618757
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5839
dc.identifier.wosWOS:001668174500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Liposome Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectJuglone
dc.subjectnanoliposome
dc.subjectbiocontrol agents
dc.subjectantibacterial
dc.subjectphytotoxicity
dc.titleNanoliposomal juglone/?-cyclodextrin complex as a biocontrol strategy against plant pathogenic bacteria
dc.typeArticle

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