Effects of ?-Lipoic Acid, vitamin E, and Selenium Combination on Inflammation-Independent ROS-Induced Damage in Kidney Tissue of Diabetic Mice

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dc.contributor.authorKacar, Ayse Karatug
dc.contributor.authorErtik, Onur
dc.contributor.authorDinckurt, Nilay
dc.contributor.authorArabaci, Unal
dc.contributor.authorYerlikaya, Pinar Obakan
dc.contributor.authorYanardag, Refiye
dc.contributor.authorBolkent, Sehnaz
dc.date.accessioned2026-02-08T15:15:42Z
dc.date.available2026-02-08T15:15:42Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractDiabetes is a metabolic and chronic disease affecting different tissues' metabolism. Genetic factors, lifestyles, and dietary habits can cause it. In diabetes, oxidative stress can occur in metabolic disorders, negatively affecting it. The antioxidants are essential in reducing or completely stopping the harmful effects of these adverse effects on the tissues. In the present study, we aimed to determine the combined effects of lipoic acid, vitamin E, and selenium in the kidneys of diabetic mice. For this experiment, the Balb/c mice were used and divided into five groups: citrate buffer, the solvents of the antioxidants, combined the antioxidants (alpha-lipoic acid, vitamin E, and selenium), streptozotocin, combined with the antioxidants and streptozotocin (A+D). At the end of 30 days of this process, the mice were sacrificed by cervical dislocation. Kidney tissues were taken for morphological, Western blotting, and biochemical analyses. The tissue was used for staining with Masson's trichrome and periodic acid-Schiff (PAS) of renal tissue sections taken for histological analysis; Western blotting such as the level of IL-10, IL-1 beta, TGF-beta, p38, cCas3, NRF2; biochemical parameters such as the level of GSH, LPO, SOD, CAT, GR, TAS, TOS, ROS, OSI, PON, CA, LDH, AR, ADA, arginase, OH-proline, and AOPP. The histological findings showed mild damage to the kidney tissue of diabetic mice. Western blot results showed that the damage was independent of inflammation. Biochemical results revealed that administering combined antioxidants to diabetic mice protects the kidney tissue.
dc.description.sponsorshipScientific Research Project Coordination Unit of Istanbul University [T-891]
dc.description.sponsorshipThis work was supported by the Scientific Research Project Coordination Unit of Istanbul University. Project No: T-891.
dc.identifier.doi10.1111/1750-3841.70544
dc.identifier.issn0022-1147
dc.identifier.issn1750-3841
dc.identifier.issue9
dc.identifier.pmid40923262
dc.identifier.scopus2-s2.0-105015366652
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/1750-3841.70544
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5913
dc.identifier.volume90
dc.identifier.wosWOS:001585366900046
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Food Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectalpha-lipoic acid
dc.subjectdiabetes
dc.subjectkidney tissue
dc.subjectmice
dc.subjectselenium
dc.subjectvitamin E
dc.titleEffects of ?-Lipoic Acid, vitamin E, and Selenium Combination on Inflammation-Independent ROS-Induced Damage in Kidney Tissue of Diabetic Mice
dc.typeArticle

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