The role of microencapsulation in maintaining biological activity of royal jelly: comparison with biological activity and bioaccessibility of microencapsulated, fresh and lyophilized forms during storage

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dc.authorid0000-0003-2038-725X
dc.authorid0000-0003-2084-7076
dc.authorid0000-0003-1126-6405
dc.authorid0000-0001-7530-7478
dc.authorid0000-0002-6777-273X
dc.authorid0000-0003-3375-8777
dc.authorid0000-0002-0290-1166
dc.contributor.authorDundar, Ayse Neslihan
dc.contributor.authorCinar, Aycan
dc.contributor.authorAltuntas, Seda
dc.contributor.authorUlubayram, Neslihan
dc.contributor.authorTaner, Gokce
dc.contributor.authorDagdelen, Adnan Fatih
dc.contributor.authorOral, Rasim Alper
dc.date.accessioned2026-02-12T21:04:59Z
dc.date.available2026-02-12T21:04:59Z
dc.date.issued2022
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractBACKGROUND Royal jelly (RJ) is a unique beehive product and has been recommended for human health since ancient times because of its antioxidant, antimicrobial, antiproliferative, neuroprotective, anti-lipidemic and anti-aging features. However, the biggest obstacle in the use of RJ is the need for cold storage and the instability of bioactive components over time. In the present study, 10-hydroxy-2-decenoic acid (10-HDA) content, as well as antioxidant [using 1,1-diphenyl-2-picrylhydrazy and 2,2 '-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) methods] and antimicrobial activity (five Gram-positive, five Gram-negative and three yeasts), were comparatively evaluated for three RJ forms, two of which can be stored at 24 +/- 1 degrees C during storage. RESULTS Microencapsulated royal jelly (MRJ) stored at room temperature succeeded in preserving its 10-HDA content, a major bioactive compound, during the 6 months, with respect to lyophilized royal jelly (LRJ) and fresh RJ stored at 4 degrees C. The initial 10-HDA contents of RJ, LRJ and MRJ were determined as 1.90%, 5.26% and 2.75%, respectively. Moreover, the total phenolic content, antioxidant capacity and antimicrobial activity mostly remained constant throughout the storage period (P >= 0.05). Gram-positive strains were generally more sensitive than Gram-negative strains. In the present study, the in vitro simulated digestion analysis showed that MRJ can tolerate the digestion process. CONCLUSION Overall, the encapsulation process was considered as one preservative technique for RJ. The microencapsulation of RJ as shown in the results of the present study are encouraging in terms of enabling the local beekeeping sector to achieve ease of production and increased product diversity. MRJ shows promise as a commercial product with a high export value for producers. (c) 2022 Society of Chemical Industry.
dc.description.sponsorshipRepublic of Turkey Ministry of Agriculture and Forestry-General Directorate of Agricultural Research and Policies (TAGEM) [18/Ar-Ge/25]
dc.description.sponsorshipWe are grateful to the Republic of Turkey Ministry of Agriculture and Forestry-General Directorate of Agricultural Research and Policies (TAGEM - Project No 18/Ar-Ge/25) for financial support of this study, which is a part of the project. Also, we thank Dr Mete Yilmaz for device support. All authors have contributed to discussion of the data and approved the final version of manuscript submitted for publication.
dc.identifier.doi10.1002/jsfa.11905
dc.identifier.endpage5511
dc.identifier.issn0022-5142
dc.identifier.issn1097-0010
dc.identifier.issue12
dc.identifier.pmid35355271
dc.identifier.scopus2-s2.0-85128376118
dc.identifier.scopusqualityQ1
dc.identifier.startpage5502
dc.identifier.urihttps://doi.org/10.1002/jsfa.11905
dc.identifier.urihttps://hdl.handle.net/20.500.12885/6748
dc.identifier.volume102
dc.identifier.wosWOS:000784171600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of The Science of Food and Agriculture
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260212
dc.subjectroyal jelly
dc.subject10-HDA
dc.subjectmicroencapsulation
dc.subjectantioxidant capacity
dc.subjectantimicrobial activity
dc.subjectbioaccessibility
dc.titleThe role of microencapsulation in maintaining biological activity of royal jelly: comparison with biological activity and bioaccessibility of microencapsulated, fresh and lyophilized forms during storage
dc.typeArticle

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