Label-free sorting of soft microparticles using a bioinspired synthetic cilia array

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dc.authorid0000-0003-1500-7347en_US
dc.contributor.authorSohrabi, Salman
dc.contributor.authorTan, Jifu
dc.contributor.authorYunus, Doruk Erdem
dc.contributor.authorHe, Ran
dc.contributor.authorLiu, Yaling
dc.date.accessioned2021-03-20T20:13:09Z
dc.date.available2021-03-20T20:13:09Z
dc.date.issued2018
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Makine Mühendisliği Bölümüen_US
dc.description2nd International Conference on Nanotechnology in Medicine -- JUN, 2018 -- Albufeira, PORTUGALen_US
dc.description.abstractIsolating cells of interest from a heterogeneous population has been of critical importance in biological studies and clinical applications. In this study, a novel approach is proposed for utilizing an active ciliary system in microfluidic devices to separate particles based on their physical properties. In this approach, the bottom of the microchannel is covered with an equally spaced cilia array of various patterns which is actuated by an external stimuli. 3D simulations are carried out to study cilia-particle interaction and isolation dynamic in a microfluidic channel. It is observed that these elastic hair-like filaments can influence particle's trajectories differently depending on their biophysical properties. This modeling study utilizes immersed boundary method coupled with the lattice Boltzmann method. Soft particles and cilia are implemented through the spring connected network model and point-particle scheme, respectively. It is shown that cilia array with proper stimulation is able to continuously and non-destructively separate cells into subpopulations based on their size, shape, and stiffness. At the end, a design map for fabrication of a programmable microfluidic device capable of isolating various subpopulations of cells is developed. This biocompatible, label-free design can separate cells/soft microparticles with high throughput which can greatly complement existing separation technologies. Published by AIP Publishing.en_US
dc.description.sponsorshipECI Confen_US
dc.description.sponsorshipNational Science FoundationNational Science Foundation (NSF) [NSF 429IIP-1701136, DMS-1516236]; National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01HL131750]; Pennsylvania Infrastructure Technology Alliance (PITA) program; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01HL131750, R01HL131750, R01HL131750, R01HL131750, R01HL131750] Funding Source: NIH RePORTERen_US
dc.description.sponsorshipThis work was partially supported by the National Science Foundation (Grant Nos. NSF 429IIP-1701136 and DMS-1516236), the National Institutes of Health (NIH) (Grant No. R01HL131750), and the Pennsylvania Infrastructure Technology Alliance (PITA) program.en_US
dc.identifier.doi10.1063/1.5022500en_US
dc.identifier.issn1932-1058
dc.identifier.issue4en_US
dc.identifier.pmid29861817en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1063/1.5022500
dc.identifier.urihttps://hdl.handle.net/20.500.12885/804
dc.identifier.volume12en_US
dc.identifier.wosWOS:000443760100008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYunus, Doruk Erdem
dc.language.isoenen_US
dc.publisherAmer Inst Physicsen_US
dc.relation.ispartofBiomicrofluidicsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleLabel-free sorting of soft microparticles using a bioinspired synthetic cilia arrayen_US
dc.typeConference Objecten_US

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