In Vitro Behavior of Boron-Doped Baghdadite/Poly(vinylidene fluoride) Membrane Scaffolds Produced via Non-Solvent Induced Phase Separation

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dc.authorid0000-0002-6685-5656
dc.contributor.authorMutlu, Busra
dc.contributor.authorDemirci, Fatma
dc.contributor.authorErginer, Merve
dc.contributor.authorDuman, Seyma
dc.date.accessioned2026-02-08T15:14:47Z
dc.date.available2026-02-08T15:14:47Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractThis study explores the potential of boron-doped baghdadite (BAG) powders incorporated into poly(vinylidene fluoride) (PVDF)-based membrane scaffolds for bone tissue engineering applications. The aim is to enhance the scaffolds' microstructure, surface wettability, thermal behavior, mechanical properties, and biological performance. Composite scaffolds are fabricated by integrating the powders into the PVDF matrix, yielding scaffolds with enhanced material characteristics and functionality. The incorporation of the powders significantly enhances the hydrophilicity of the scaffolds, as evidenced by a notable reduction in contact angle measurements. Mechanical analyses demonstrate that the addition of boron-doped BAG powders reduces the tensile strength and elongation at the break of PVDF scaffolds, attribute to increased pore size, reduced crystallinity, and structural heterogeneity, though the values remain within the range of human cancellous bone. Furthermore, in vitro bioactivity studies reveal the superior apatite-forming ability of the composite scaffolds, indicating their enhanced potential for biomineralization. The results of the cellular adhesion assays indicate an enhanced affinity and proliferation of cells on the membrane scaffolds, which is indicative of improved biocompatibility. In conclusion, the developed PVDF-based membrane scaffolds, reinforce with BAG powders, show promise as effective alternatives to traditional bone graft materials, offering scalable and versatile solutions for regenerative medicine.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK) [2211-C]; TUBIdot;TAK [124M221]
dc.description.sponsorshipThis study was part of the doctoral thesis research of Busra Mutlu at the Department of Metallurgical and Materials Engineering, Bursa Technical University. The authors gratefully acknowledge the support of the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK) for funding Busra Mutlu through the 2211-C Priority Areas Doctoral Program Scholarship. The authors are thankful to the Central Research Laboratory at Bursa Technical University for providing the essential laboratory facilities required for this research. This work was financially supported by the TUB & Idot;TAK (Grant No.124M221).
dc.identifier.doi10.1002/mabi.202400619
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.issue9
dc.identifier.pmid40404602
dc.identifier.scopus2-s2.0-105006451195
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/mabi.202400619
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5432
dc.identifier.volume25
dc.identifier.wosWOS:001492979000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofMacromolecular Bioscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectbiocompatibility
dc.subjectboron-doped baghdadite
dc.subjectmembrane scaffolds
dc.subjectNIPS (non-solvent induced phase separation)
dc.subjectPVDF
dc.titleIn Vitro Behavior of Boron-Doped Baghdadite/Poly(vinylidene fluoride) Membrane Scaffolds Produced via Non-Solvent Induced Phase Separation
dc.typeArticle

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