PVA/Inulin-Based Sustainable Films Reinforced with Pickering Emulsion of Niaouli Essential Oil for Potential Wound Healing Applications

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dc.authorid0000-0001-7068-2471
dc.authorid0000-0003-2244-4369
dc.authorid0000-0003-2126-0381
dc.authorid0000-0002-0788-5708
dc.authorid0000-0002-1370-7588
dc.authorid0000-0003-2187-0681
dc.contributor.authorParin, Fatma Nur
dc.contributor.authorEl-Ghazali, Sofia
dc.contributor.authorYesilyurt, Aysenur
dc.contributor.authorParin, Ugur
dc.contributor.authorUllah, Azeem
dc.contributor.authorKhatri, Muzamil
dc.contributor.authorKim, Ick Soo
dc.date.accessioned2026-02-12T21:05:33Z
dc.date.available2026-02-12T21:05:33Z
dc.date.issued2023
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractIn this study, sustainable water-based films were produced via the solvent-casting method. Petroleum-free-based polyvinyl alcohol (PVA) and carbohydrate-based inulin (INL) were used as matrices. Vegetable-waste pumpkin powder was used in the study because of its sustainability and antibacterial properties. Pickering emulsions were prepared using beta-cyclodextrin. The influence of the different ratios of the beta-cyclodextrin/niaouli essential oil (beta-CD/NEO) inclusion complex (such as 1:1, 1:3, and 1:5) on the morphological (SEM), thermal (TGA), physical (FT-IR), wettability (contact angle), and mechanical (tensile test) characteristics of PVA/inulin films were investigated. Moreover, the antibacterial activities against the Gram (-) (Escherichia coli and Pseudomonas aeruginosa) and Gram (+) (Staphylococcus aureus) bacteria of the obtained films were studied. From the morphological analysis, good emulsion stability and porosity were obtained in the Pickering films with the highest oil content, while instability was observed in the Pickering films with the lowest concentration of oil content. Thermal and spectroscopic analysis indicated there was no significant difference between the Pickering emulsion films and neat films. With the addition of Pickering emulsions, the tensile stress values decreased from 7.3 +/- 1.9 MPa to 3.3 +/- 0.2. According to the antibacterial efficiency results, films containing pumpkin powder and Pickering emulsion films containing both pumpkin powder and a ratio of 1:1 (beta-CD/NEO) did not have an antibacterial effect, while Pickering emulsion films with a ratio of (beta-CD/NEO) 1:3 and 1:5 showed an antibacterial effect against Escherichia coli, with a zone diameter of 12 cm and 17 cm, respectively. Among the samples, the films with ratio of (beta-CD/NEO) 1:5 had the highest antioxidant capacity, as assessed by DPPH radical scavenging at 12 h intervals. Further, none of the samples showed any cytotoxic effects the according to LDH and WST-1 cytotoxicity analysis for the NIH3T3 cell line. Ultimately, it is expected that these films are completely bio-based and may be potential candidates for use in wound healing applications.
dc.identifier.doi10.3390/polym15041002
dc.identifier.issn2073-4360
dc.identifier.issue4
dc.identifier.pmid36850285
dc.identifier.scopus2-s2.0-85149042438
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/polym15041002
dc.identifier.urihttps://hdl.handle.net/20.500.12885/7027
dc.identifier.volume15
dc.identifier.wosWOS:000940946000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260212
dc.subjectPVA
dc.subjectinulin
dc.subjectPickering emulsions
dc.subjectpumpkin powder
dc.subjectniaouli essential oil
dc.subjectsustainable film
dc.titlePVA/Inulin-Based Sustainable Films Reinforced with Pickering Emulsion of Niaouli Essential Oil for Potential Wound Healing Applications
dc.typeArticle

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