Treatment of oxidative damage caused by valproic acid in tongue tissue with ethanolic Moringa oleifera leaves extract and prediction of potential bioactive molecules with molecular docking

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dc.authorid0000-0001-6503-4613
dc.authorid0000-0002-4009-481X
dc.authorid0000-0002-3408-7867
dc.authorid0000-0001-6503-4613
dc.authorid0000-0001-5437-3513
dc.contributor.authorErtik, Onur
dc.contributor.authorKoroglu, Pinar
dc.contributor.authorMagaji, Umar Faruk
dc.contributor.authorBulan, Nihal Omur
dc.contributor.authorSacan, Ozlem
dc.contributor.authorYanardag, Refiye
dc.date.accessioned2026-02-08T15:14:57Z
dc.date.available2026-02-08T15:14:57Z
dc.date.issued2024
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractMoringa oleifera (M. oleifera) is a popular medicinal plant that has become a wide research area in recent years due to its detected biological effects and its bioactive compounds. Valproic acid (VPA) is a medication used in the treatment of epilepsy and bipolar disorder and high doses or prolonged use of VPA can result in oxidative stress in cells. Since M. oleifera has high biological activities and contains many bioactive compounds, it is necessary to understand whether it plays a role in reducing oxidative damage, especially that caused VPA. The relationship between VPA and tongue tissue needs to be investigated, since VPA has negative effects on oral health and it is known that tongue tissue plays an important role in the continuity of oral health. In the present study, 3.0-3.5 month-old female Sprague Dawley rats (160-250 g) were divided into four groups (Control, Moringa, VPA, VPA + M), and VPA was administered via gavage. The aim was to understand the protective/preventive effects of ethanolic M. oleifera leaves extract against oxidative stress through biochemical parameters. Additionally, molecular docking studies were conducted on niazicin-A, niazimin-A, and niazimin-B found in M. oleifera leaves based on in vivo results. The results indicate that M. oleifera extract treats oxidative damage to the tongue tissue, and niazimin-A and niazimin-B particularly show high binding affinities to myeloperoxidase (MPO) and lactate dehydrogenase (LDH) enzymes. Further studies may suggest that the use of M. oleifera leaves extract with VPA could prevent potential negative effects on tongue tissue.
dc.identifier.doi10.1007/s10735-024-10277-3
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue1
dc.identifier.pmid39661285
dc.identifier.scopus2-s2.0-85211462293
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10735-024-10277-3
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5527
dc.identifier.volume56
dc.identifier.wosWOS:001374824500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectMoringa oleifera
dc.subjectValproic acid
dc.subjectTongue tissue
dc.subjectOxidative stress
dc.subjectMolecular docking
dc.titleTreatment of oxidative damage caused by valproic acid in tongue tissue with ethanolic Moringa oleifera leaves extract and prediction of potential bioactive molecules with molecular docking
dc.typeArticle

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