DEVELOPMENT AND CHARACTERIZATION OF VITAMIN B9 - ELECTROSPRAYED NON-WOVEN SURFACES FOR WOUND HEALING APPLICATIONS

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dc.contributor.authorParın, Fatma Nur
dc.contributor.authorYıldırım, Kenan
dc.contributor.authorTaner, Gökçe
dc.contributor.authorKıldalı, Elife
dc.date.accessioned2026-02-08T15:03:10Z
dc.date.available2026-02-08T15:03:10Z
dc.date.issued2021
dc.departmentBursa Teknik Üniversitesi
dc.description190D003
dc.description.abstractIn this study, novel wound dressing materials based on non-woven (NW) surfaces were developed using electrospraying (e-spraying) process. Polyester spunbond (PET SPB), polypropylene spunbond (PP SPB), and polypropylene melt-blown (PP MB) surfaces used as matrix, and folic acid (FA), vitamin B9 were sprayed on these surfaces. The resulting NW fabrics with the same FA content were investigated in terms of chemical, morphological, thermal, wettability properties. Scanning Electron Microscopy and (SEM) and Fourier Transform Infrared (FT-IR) spectroscopy results showed formation of physical interaction between NWs and FA is successfully deposited onto NWs with average fiber diameters from 2.6 µm to 23.11 µm. According to the thermogravimetric analysis (TGA) FA loaded-PP SPB have enhaced thermal stability compared to pure one (PP SPB). The FA-loaded surfaces have hydrophobic property with contact angles values more than >90°. The in-vitro release was carried out by UV-Vis within the 8 hour-period phosphate buffer saline (pH 7.2). The results indicated that FA-loaded surfaces have a fast release behaviour. The total FA release amounts of the FA-loaded PET SBP, PP SPB and PP MB NWs were found as 22.8, 17.1, and 17.5 ppm. Moreover, biocompatibility of all resulting NW surfaces was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red uptake (NRU) cytotoxicity tests in L929 cell lines. The obtained NWs have biocompatible and non-toxic material except PET SPB-sFA.The study indicated that FA-loaded NWs can be potential candidates for wound healing applications.
dc.description.sponsorshipBursa Technical University
dc.identifier.doi10.18038/estubtda.983329
dc.identifier.endpage84
dc.identifier.issn2667-4211
dc.identifier.issueVol:22- 8th ULPAS - Special Issue 2021
dc.identifier.startpage70
dc.identifier.trdizinid522277
dc.identifier.urihttps://doi.org/10.18038/estubtda.983329
dc.identifier.urihttps://hdl.handle.net/20.500.12885/3915
dc.identifier.volume22
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherEskişehir Teknik Üniversitesi
dc.relation.ispartofEskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20260207
dc.subjectEngineering
dc.subjectMühendislik
dc.titleDEVELOPMENT AND CHARACTERIZATION OF VITAMIN B9 - ELECTROSPRAYED NON-WOVEN SURFACES FOR WOUND HEALING APPLICATIONS
dc.title.alternativeDEVELOPMENT AND CHARACTERIZATION OF VITAMIN B9 - ELECTROSPRAYED NON-WOVEN SURFACES FOR WOUND HEALING APPLICATIONS
dc.typeArticle

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