DEVELOPMENT AND CHARACTERIZATION OF VITAMIN B9 - ELECTROSPRAYED NON-WOVEN SURFACES FOR WOUND HEALING APPLICATIONS
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Eskişehir Teknik Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, novel wound dressing materials based on non-woven (NW) surfaces were developed using electrospraying (e-spraying) process. Polyester spunbond (PET SPB), polypropylene spunbond (PP SPB), and polypropylene melt-blown (PP MB) surfaces used as matrix, and folic acid (FA), vitamin B9 were sprayed on these surfaces. The resulting NW fabrics with the same FA content were investigated in terms of chemical, morphological, thermal, wettability properties. Scanning Electron Microscopy and (SEM) and Fourier Transform Infrared (FT-IR) spectroscopy results showed formation of physical interaction between NWs and FA is successfully deposited onto NWs with average fiber diameters from 2.6 µm to 23.11 µm. According to the thermogravimetric analysis (TGA) FA loaded-PP SPB have enhaced thermal stability compared to pure one (PP SPB). The FA-loaded surfaces have hydrophobic property with contact angles values more than >90°. The in-vitro release was carried out by UV-Vis within the 8 hour-period phosphate buffer saline (pH 7.2). The results indicated that FA-loaded surfaces have a fast release behaviour. The total FA release amounts of the FA-loaded PET SBP, PP SPB and PP MB NWs were found as 22.8, 17.1, and 17.5 ppm. Moreover, biocompatibility of all resulting NW surfaces was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red uptake (NRU) cytotoxicity tests in L929 cell lines. The obtained NWs have biocompatible and non-toxic material except PET SPB-sFA.The study indicated that FA-loaded NWs can be potential candidates for wound healing applications.
Açıklama
190D003
Anahtar Kelimeler
Engineering, Mühendislik
Kaynak
Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering
WoS Q Değeri
Scopus Q Değeri
Cilt
22
Sayı
Vol:22- 8th ULPAS - Special Issue 2021
