Preparation, Characterization, and Antimicrobial Activities of Ceragenins Incorporated Into Polyvinyl Alcohol/Gelatin/Sodium Alginate-Based Hydrogels for Treatment of Burn Wounds

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dc.authorid0000-0001-8406-149X
dc.contributor.authorAljayyousi, Nawal
dc.contributor.authorIrmak, Emel Tamahkar
dc.contributor.authorOzer, Elif Tumay
dc.contributor.authorCinar, Aycan Yigit
dc.contributor.authorGuzel, Cagla Bozkurt
dc.contributor.authorSavage, Paul B.
dc.contributor.authorOsman, Bilgen
dc.date.accessioned2026-02-08T15:14:45Z
dc.date.available2026-02-08T15:14:45Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractCeragenins are synthetic molecules that mimic antimicrobial peptides (AMPs) in the human immune system. They feature a bile acid-based structure with appended positively charged groups that disrupt bacterial cell membranes, leading to microbial cell death or inactivation. In this study, ceragenin CSA-44 was incorporated into a polyvinyl alcohol (PVA)/gelatin (G)/sodium alginate (SA)-based hydrogel (PGA-CSA). The hydrogel was cross-linked with glutaraldehyde (GA) for 20 min using a 0.125% GA (v/v) solution. The optimized volume ratios of the polymer solutions in the hydrogel were determined to be 2:1:3 (PVA:SA:G). PGA-CSA and PGA hydrogels were characterized using scanning electron microscopy (SEM), mercury porosimetry, and Fourier transform infrared spectroscopy (FTIR). The maximum swelling ratio of PGA-CSA was 780.48% +/- 14.80%, and the WVTR value was 905.4 +/- 35.4 g/m2/d. Drug release studies showed a cumulative CSA-44 release of 29.07% over 7 days. The antibacterial activity of the hydrogel was tested against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 19151, Staphylococcus aureus ATCC 29213, and MRSA. The tested bacteria were inhibited within 2, 2.5, 3, and 3.5 h, respectively. The developed PGA-CSA hydrogel demonstrated outstanding potential and unique characteristics as an antibacterial dressing for burn wounds.
dc.description.sponsorshipBursa Uludagbreve; niversitesi [FOA-2022-1097]; Research Foundation of Bursa Uludag University
dc.description.sponsorshipThis work was supported by the Research Foundation of Bursa Uludag University (Project No: FOA-2022-1097).
dc.identifier.doi10.1002/app.57129
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue27
dc.identifier.scopus2-s2.0-105002248125
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.57129
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5409
dc.identifier.volume142
dc.identifier.wosWOS:001461764500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectbioengineering
dc.subjectbiomaterials
dc.subjectdrug delivery systems
dc.titlePreparation, Characterization, and Antimicrobial Activities of Ceragenins Incorporated Into Polyvinyl Alcohol/Gelatin/Sodium Alginate-Based Hydrogels for Treatment of Burn Wounds
dc.typeArticle

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