?-Glycosidase activity of novel coumarin-triazole-coumarin dyads

Basit Öğe Kaydı
dc.contributor.authorSirin, Ersin
dc.contributor.authorSevimli, Esra
dc.contributor.authorSeyhan, Gokce
dc.contributor.authorBarut, Burak
dc.contributor.authorKaya, Yunus
dc.contributor.authorKoksoy, Baybars
dc.date.accessioned2026-02-08T15:16:04Z
dc.date.available2026-02-08T15:16:04Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractNovel coumarin-triazole-coumarin dyads were synthesized and characterized, and their alpha-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC50value of 38.98 +/- 0.77 mu M. The IC50 values for 4d and 4a were 93.55 +/- 1.70 mu M and 95.04 +/- 3.55 mu M, respectively. The Lineweaver-Burk plot showed that 4e inhibited alpha-glycosidase in a mixed type. In addition, the Ki value obtained from the Dixon plot was 19.95 +/- 0.15 mu M for alpha-glycosidase.
dc.description.sponsorshipBursa Technical University Scientific Research Fund [210Y016]
dc.description.sponsorshipAcknowledgment Bursa Technical University Scientific Research Fund (Grant Number 210Y016) is gratefully acknowledged.
dc.identifier.doi10.55730/1300-0527.3770
dc.identifier.issn1300-0527
dc.identifier.issue6
dc.identifier.pmid41510060
dc.identifier.scopus2-s2.0-105027368443
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3770
dc.identifier.urihttps://hdl.handle.net/20.500.12885/6123
dc.identifier.volume49
dc.identifier.wosWOS:001667219800008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectCoumarin
dc.subjecttriazole
dc.subjectenzyme inhibition
dc.subjectalpha-glycosidase
dc.title?-Glycosidase activity of novel coumarin-triazole-coumarin dyads
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu