Moringa oleifera ameliorates oxidative damage caused by sodium valproate in the small intestine

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dc.authorid0000-0001-5437-3513
dc.authorid0000-0001-6503-4613
dc.authorid0000-0002-5054-2604
dc.contributor.authorCoremen, Melis
dc.contributor.authorErtik, Onur
dc.contributor.authorMagaji, Umar Faruk
dc.contributor.authorSacan, Ozlem
dc.contributor.authorBulan, Omur Karabulut
dc.contributor.authorYanardag, Refiye
dc.date.accessioned2026-02-08T15:15:35Z
dc.date.available2026-02-08T15:15:35Z
dc.date.issued2026
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractThis study aimed to investigate the protective effects of Moringa oleifera (MO) extract against valproic acid (VPA)-induced small intestine damage in rats. Forty-six adult female Sprague-Dawley rats were divided into four groups: Control (saline), MO (300 mg/kg), VPA (500 mg/kg), and VPA + MO. All treatments were administered orally for 15 days. Biochemical oxidative stress analyses revealed that MO treatment mitigated oxidative stress in VPA-treated rats. Molecular docking studies demonstrated that bioactive compounds in MO leaves exhibited potential inhibitory activity against oxidative stress-related enzymes, with high binding affinities. Immunohistochemical results indicated that VPA did not alter antioxidant stress responses such as Nrf2. However, histological examinations showed that VPA caused structural damage to the small intestine, while MO treatment alleviated this effect. Overall, MO exhibited significant protective and antioxidant properties against VPA-induced intestinal injury.
dc.description.sponsorshipIstanbul University Scientific Research Projects Unit [FBA-2021-37282]
dc.description.sponsorshipThis project was supported by Istanbul University Scientific Research Projects Unit with the code FBA-2021-37282.
dc.identifier.doi10.1080/13813455.2025.2610475
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.pmid41503823
dc.identifier.scopus2-s2.0-105027137328
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/13813455.2025.2610475
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5860
dc.identifier.wosWOS:001656442900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectValproic acid
dc.subjectMoringa oleifera
dc.subjectsmall intestine injury
dc.subjectNrf2
dc.subjectoxidative stress
dc.titleMoringa oleifera ameliorates oxidative damage caused by sodium valproate in the small intestine
dc.typeArticle

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