Characterization and antibacterial activity of gelatin–gellan gum bilayer wound dressing

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dc.authorid0000-0002-5913-8333en_US
dc.authorscopusid36189141400en_US
dc.contributor.authorÖzkahraman B.
dc.contributor.authorÖzbaş Z.
dc.contributor.authorBayrak G.
dc.contributor.authorTamahkar, Emel
dc.contributor.authorPerçin I.
dc.contributor.authorKılıç Süloğlu A.
dc.contributor.authorBoran F.
dc.date.accessioned2022-04-05T06:50:22Z
dc.date.available2022-04-05T06:50:22Z
dc.date.issued2022en_US
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.description.abstractBilayer wound dressing systems consisting of various biopolymers have been preferred in biomedical applications due to its enhanced advantages in comparison with conventional systems. The aim of this research was to develop a novel bilayer wound dressing based on gelatin (G) and gellan gum (GG). The bilayer was composed of an upper layer impregnated with antibiotic drug sodium ampicillin and a drug-free lower sponge layer. The bilayer hydrogels were characterized by FTIR, TGA, DSC and SEM analyses including swelling behaviors and hydrolytic degradation tests. To achieve faster healing of the wound by prevention of the bacterial infection, the bilayer hydrogels were developed as antibiotic-releasing vehicles. Herein, release study of sodium ampicillin was performed in PBS to simulate the physiological micro-environment. Additionally, cyto-compatibility tests of L929 fibroblast cells showed the high proliferation and survival through drug-loaded GG and G hydrogels (GG-G-D) after 24h, 48h and 72h incubation. This novel GG-G bilayer hydrogel could be a good candidate as wound dressing.en_US
dc.identifier.doi10.1080/00914037.2021.1960341en_US
dc.identifier.endpage1251
dc.identifier.issn00914037
dc.identifier.issue16
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1240
dc.identifier.urihttps://hdl.handle.net/20.500.12885/1858
dc.identifier.volume71
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTamahkar, Emel
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectbilayer wound dressing materialsen_US
dc.subjectcontrolled drug deliveryen_US
dc.subjectMTT assayen_US
dc.titleCharacterization and antibacterial activity of gelatin–gellan gum bilayer wound dressingen_US
dc.typeArticleen_US

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