Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin

Basit Öğe Kaydı
dc.authorid0000-0003-1858-0691en_US
dc.authorscopusid55307699800en_US
dc.contributor.authorAltinkok C.
dc.contributor.authorAcik G.
dc.contributor.authorKarabulut H.R.F.
dc.contributor.authorÇiftci, Mustafa
dc.contributor.authorTasdelen M.A.
dc.contributor.authorDag A.
dc.date.accessioned2022-01-20T08:18:33Z
dc.date.available2022-01-20T08:18:33Z
dc.date.issued2021en_US
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Bölümüen_US
dc.description.abstractIn the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.en_US
dc.identifier.doi10.1002/pat.5478en_US
dc.identifier.endpage4868en_US
dc.identifier.issn10427147
dc.identifier.issue12en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage4860en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12885/1800
dc.identifier.volume32en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇiftçi, Mustafa
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.relation.ispartofPolymers for Advanced Technologiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamphiphilicen_US
dc.subjectdrug releaseen_US
dc.subjectlithocholic aciden_US
dc.subjectphotopolymerizationen_US
dc.titleSynthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicinen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Orman Mühendisliği Bölümü Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu