Two-tier combinatorial structure to integrate various gene co-expression networks of prostate cancer

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dc.authorid0000-0003-4469-1440en_US
dc.contributor.authorCingiz, Mustafa Özgür
dc.contributor.authorDiri, Banu
dc.date.accessioned2021-03-20T20:12:24Z
dc.date.available2021-03-20T20:12:24Z
dc.date.issued2019
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümüen_US
dc.description.abstractAdvances in DNA sequencing technologies enable researchers to integrate various biological datasets in order to reveal hidden relations at the molecular level. In this study, we present a two-tiered combinatorial structure (TTCS) to integrate gene co-expression networks (GCNs) that are inferred from microarray gene expression, RNA-Seq and miRNA-target gene data. In the initial phase of TTCS, we derive GCNs by using gene network inference (GNI) algorithms for each dataset. In the first and second integration phases, we use straightforward methods: intersection, union and simple majority voting to combine GCNs. We use overlap, topological and biological analyses in performance evaluation and investigate the integration effects of GCNs separately for all phases. Our results prove that the first integration phase has limited contribution on performance. However, combining the biological datasets in the second phase significantly enhances the overlap and topological performance analyses.en_US
dc.identifier.doi10.1016/j.gene.2019.144102en_US
dc.identifier.issn0378-1119
dc.identifier.issn1879-0038
dc.identifier.pmid31499125en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1016/j.gene.2019.144102
dc.identifier.urihttps://hdl.handle.net/20.500.12885/532
dc.identifier.volume721en_US
dc.identifier.wosWOS:000496866400009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCingiz, Mustafa Özgür
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofGeneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGene co-expression networken_US
dc.subjectGene network inferenceen_US
dc.subjectEnsemble based decision makingen_US
dc.subjectOverlap analysisen_US
dc.subjectTopological featuresen_US
dc.titleTwo-tier combinatorial structure to integrate various gene co-expression networks of prostate canceren_US
dc.typeArticleen_US

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