Design and Development of Pulsatile Cardiovascular Flow Simulator and Comparative Assessment of Flow through Stenosed Blood Vessel

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dc.contributor.authorBit, A.
dc.contributor.authorChattopadhyay, H.
dc.contributor.authorDeshmukh, K.
dc.contributor.authorMukherjee, R.
dc.contributor.authorBenim, A. C.
dc.date.accessioned2026-02-08T15:15:43Z
dc.date.available2026-02-08T15:15:43Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractThe design, development, and validation of a physiological pulsatile cardiovascular flow simulator to analyse the hemodynamic behaviour in stenosed blood vessels is studied. The simulator consists of an innovative arrangement of peristaltic pumps to reproduce realistic arterial pulse waveforms, incorporating the higher harmonic components of physiological flow. Experimental investigations were performed using a laser Doppler velocimetry (LDV) system to evaluate the axial velocity, the wall shear stress (WSS), the turbulence intensity, and related flow parameters in vessels with varying stenosis severities (12.5, 25, and 50%). The observed results indicated that stenosis severity critically influences the flow structure, with higher blockages inducing significant velocity skewness, increased oscillatory WSS, and sustained post-stenotic disturbances. Flow reversal, vortex formation, and prolonged laminar recovery were observed downstream of severe stenoses. Comparative analyses with theoretical models validated the experimental accuracy, particularly in central and mid-radial zones. The study also introduced a method for determining the oscillatory shear index (OSI) and the relative residence time (RRT), identifying regions susceptible to atherogenesis. The simulator provides a reliable platform for replicating in vivo-like flow patterns in vitro, providing the valuable insights into the disease progression mechanisms and enabling future development of diagnostic and interventional strategies in cardiovascular medicine.
dc.description.sponsorshipDepartment of Science and Technology, India [DST-SERB/ECR/ 00115]
dc.description.sponsorshipThis study was supported by the Department of Science and Technology, India (project no. DST-SERB/ECR/ 00115).
dc.identifier.doi10.1134/S0015462825602037
dc.identifier.issn0015-4628
dc.identifier.issn1573-8507
dc.identifier.issue6
dc.identifier.scopus2-s2.0-105023878258
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1134/S0015462825602037
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5926
dc.identifier.volume60
dc.identifier.wosWOS:001630175800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Ltd
dc.relation.ispartofFluid Dynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectpulsatile flow simulator
dc.subjectstenosed blood vessel
dc.subjectwall shear stress (WSS)
dc.subjectoscillatory shear index (OSI)
dc.subjectrelative residence time (RRT)
dc.subjectflow separation
dc.titleDesign and Development of Pulsatile Cardiovascular Flow Simulator and Comparative Assessment of Flow through Stenosed Blood Vessel
dc.typeArticle

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