The protective effects of Myrtus communis subsp. on ovariectomized diabetic rats' renal and intestinal tissues: in vivo and in silico approaches

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dc.authorid0000-0002-2144-5741
dc.authorid0000-0001-7444-6193
dc.authorid0000-0001-8887-4826
dc.authorid0000-0001-5437-3513
dc.contributor.authorErtik, Onur
dc.contributor.authorKadioglu-Yaman, Beril
dc.contributor.authorSen, Ali
dc.contributor.authorSener, Goksel
dc.contributor.authorYanardag, Refiye
dc.date.accessioned2026-02-08T15:15:35Z
dc.date.available2026-02-08T15:15:35Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractIntroductionPostmenopausal diabetes is a condition that affects millions of women and their quality of life. Also, kidney and small intestine tissues are damaged due to diabetes. The present study aimed to examine the protective effects of an extract prepared from Myrtus communis leaves on kidney and small intestine tissues against experimentally created postmenopausal diabetes. MethodsFor this purpose, experimental rats were randomly divided into six groups (Control; ovariectomy:OVX, diabetic:D, ovariectomy + diabetic:OVX + D, ovariectomy + diabetic + oestrogen:OVX + D+E2, ovariectomy + diabetic + MC: OVX + D+MC) and kidney and small intestine tissues were taken after the experimental procedure. ResultsEvaluations of biochemical parameters (glutathione and glutathione-related enzymes, antioxidant enzymes, etc.) showed that MC had a protective effect on kidney and small intestine tissues in diabetes and ovariectomy groups. ConclusionIt can be suggested that MC extract has a protective effect on small intestine and kidney tissues in postmenopausal diabetes and may be a good herbal source for this purpose.
dc.identifier.doi10.1080/13813455.2024.2406895
dc.identifier.endpage226
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue2
dc.identifier.pmid39324246
dc.identifier.scopus2-s2.0-105002050453
dc.identifier.scopusqualityQ1
dc.identifier.startpage210
dc.identifier.urihttps://doi.org/10.1080/13813455.2024.2406895
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5859
dc.identifier.volume131
dc.identifier.wosWOS:001320739100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectMyrtus communis
dc.subjectdiabetes
dc.subjectoxidative stress
dc.subjectovariectomize
dc.subjectin silico
dc.titleThe protective effects of Myrtus communis subsp. on ovariectomized diabetic rats' renal and intestinal tissues: in vivo and in silico approaches
dc.typeArticle

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