Synthesis, characterization, colorimetric sensor and acetylcholinesterase inhibition studies of novel benzimidazole-based hydroxamic acids

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dc.authorid0000-0002-7711-0975
dc.contributor.authorYilmaz, Fatih
dc.contributor.authorKizil, Demet
dc.contributor.authorDincer, Barbaros
dc.contributor.authorKaraoglu, Kaan
dc.date.accessioned2026-02-08T15:15:20Z
dc.date.available2026-02-08T15:15:20Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractTwo new hydroxamic acid molecules 2-(2-Pyridyl)benzimidazole-N-acetohydroxamic acid (HL1), 2-(2-Pyridyl) benzimidazole-N-butanohydroxamic acid (HL2), can be used in Fe(III) detection and pest control, have been synthesized first time and characterized using Elemental Analysis, 1H NMR, 13C NMR, FT-IR, LC-MS (ESI+) spectrometry. Selectivity of the HL1 and HL2 towards Fe3+ ion were tested against in the presence of the competitive metal ions and found to be highly effective agents for the determination of Fe3+ ions in the presence of these ions. The limits of detection of Fe(III) ions using these ligands were found 1.9 mu M and 0.7 mu M, respectively. Metal complexes of HL1 and HL2 with Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) were also synthesized to understand the complex formation in the solid phase and at higher pH. The results showed in the solid phase the M:L ratios of the complexes were 1:1 and 1:2 and the hydroxamate groups were in the keto form. The inhibition effects of HL1 and HL2 ligands on acetylcholinesterase (AChE) purified from Orosanga japonica (Melichar, 1898) (Homoptera: Ricaniidae) were determined. The ligands effectively inhibited acetylcholinesterase yet HL1 was more effective than HL2, IC50 values of 1.7 +/- 0.2 mM and 2.6 +/- 0.1 mM, respectively. These results indicated these newly synthesized benzimidazole-based hydroxamic acid ligands can serve as dualfunctional agents for both Fe3+ detection and pest control.
dc.identifier.doi10.1016/j.jics.2025.102033
dc.identifier.issn0019-4522
dc.identifier.issue10
dc.identifier.scopus2-s2.0-105013669889
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jics.2025.102033
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5730
dc.identifier.volume102
dc.identifier.wosWOS:001561429400002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of The Indian Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectHydroxamic acid
dc.subjectHydroxamate
dc.subjectColorimetric sensor
dc.subjectBenzimidazole
dc.subjectAcetylcholinesterase inhibition
dc.titleSynthesis, characterization, colorimetric sensor and acetylcholinesterase inhibition studies of novel benzimidazole-based hydroxamic acids
dc.typeArticle

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