Mechanical deviation in 3D-Printed PLA bone scaffolds during biodegradation

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dc.contributor.authorSenaysoy, Safa
dc.contributor.authorİLhan, Recep
dc.contributor.authorLekesiz, Huseyin
dc.date.accessioned2026-02-08T15:11:10Z
dc.date.available2026-02-08T15:11:10Z
dc.date.issued2024
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractLarge or carcinogenic bone defects may require a challenging bone tissue scaffold design ensuring a proper mechanobiological setting. Porosity and biodegradation rate are the key parameters controlling the bone-remodeling process. PLA presents a great potential for geometrically flexible 3-D scaffold design. This study aims to investigate the mechanical variation throughout the biodegradation process for lattice-type PLA scaffolds using both experimental observations and simulations. Three different unit-cell geometries are used for creating the scaffolds: basic cube (BC), body-centered structure (BCS), and body-centered cube (BCC). Three different porosity ratios, 50 %, 62.5 %, and 75 %, are assigned to all three structures by altering their strut dimensions. 3-D printed scaffolds are soaked in PBS solution at 37 °C for 15, 30, 60, 90, and 120 days both unloaded and under dead load. Water absorption, weight loss, and compression stiffness are measured to characterize the first-stage degradation and investigate the possible influences of these parameters on the whole biodegradation process. The strength reduction stage of biodegradation is simulated by solving pseudo-first-order kinetics-based molecular weight change equation using FEA with equisized cubic (voxel-like) elements. For the first stage, mechanical load does not have a statistically significant effect on biodegradation. BCC with 62.5 % porosity shows a maximum water absorption rate of around 25 % by the 60th day which brings an advantage in creating an aquatic environment for cell growth. Results indicate a significant water deposition inside almost all scaffolds and water content is determined to be the main reason for the retained or increased compression stiffness. A distinguishable stiffness increase in the initial degradation process occurs for 75 % porous BC and 50 % porous BCC scaffolds. Following the quasi-stable stage of biodegradation, almost all scaffolds lost their rigidity by around 44–48 % within 120 days based on numerical results. Therefore, initial stiffness increase in the quasi-stable stage of biodegradation can be advantageous and BCC geometry with a porosity between 50% and 62 % is the optimum solution for the whole biodegradation process. © 2024 Elsevier Ltd
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK, (222M025); Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK; (210ÖAP006)
dc.identifier.doi10.1016/j.compbiomed.2024.109227
dc.identifier.issn0010-4825
dc.identifier.pmid39369546
dc.identifier.scopus2-s2.0-85205455430
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.compbiomed.2024.109227
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5259
dc.identifier.volume183
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofComputers in Biology and Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_KA_20260207
dc.subject3-D printing
dc.subjectBiodegradation
dc.subjectBone scaffold
dc.subjectFinite element analysis
dc.subjectLattice structures
dc.subjectPLA
dc.subjectWater absorption
dc.titleMechanical deviation in 3D-Printed PLA bone scaffolds during biodegradation
dc.typeArticle

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