Poly(vinyl alcohol)/(hyaluronic acid-g-kappa-carrageenan) hydrogel as antibiotic-releasing wound dressing

Basit Öğe Kaydı
dc.authorid0000-0002-5913-8333en_US
dc.authorscopusid36189141400en_US
dc.contributor.authorÖzbaş Z
dc.contributor.authorÖzkahraman B.
dc.contributor.authorBayrak G.
dc.contributor.authorKılıç Süloğlu A.
dc.contributor.authorPerçin I.
dc.contributor.authorBoran F.
dc.contributor.authorTamahkar, Emel
dc.date.accessioned2022-01-20T08:26:46Z
dc.date.available2022-01-20T08:26:46Z
dc.date.issued2021en_US
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.description.abstractThe aim of this research was to investigate the potential of ampicillin-loaded hydrogels based on polyvinyl alcohol (PVA), hyaluronic acid (HA) and kappa-carrageenan (K-Carr) as an antibiotic-releasing wound dressing. Firstly, the novel polymers (HA-g-K-Carr) were synthesized by grafting of HA onto K-Carr using 4-dimethylaminopyridine/1-(3-dimethylaminopyl)-3-ethyl-carbodiimide hydrochloride as catalyst system via esterification reaction. The characterization of the polymer structure was performed by Fourier transform infrared spectrum (FTIR), proton nuclear magnetic resonance and thermogravimetric analysis. Secondly, PVA/(HA-g-K-Carr) hydrogel with/without loading of ampicillin molecules was formed via freeze–thawing method since PVA/K-Carr and PVA/HA hydrogels were also fabricated as control groups. The hydrogels were subjected to characterizations with FTIR and X-ray diffractometer. PVA/(HA-g-K-Carr) hydrogel demonstrated the highest swelling amount and highest ampicillin release amount reaching an equilibrium value after 480 min rather than the other hydrogels. Also, PVA/(HA-g-K-Carr) hydrogel exhibited inhibition zone against Escherichia coli and Staphylococcus aureus and no cytotoxic effect for L929 cells. All the results showed that PVA/(HA-g-K-Carr) hydrogels are good candidates for wound dressing applications.en_US
dc.identifier.doi10.1007/s11696-021-01824-3en_US
dc.identifier.endpage6600en_US
dc.identifier.issn03666352
dc.identifier.issue12en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6591en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12885/1801
dc.identifier.volume75en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTamahkar, Emel
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofChemical Papersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial activityen_US
dc.subjectCell viabilityen_US
dc.subjectHyaluronic aciden_US
dc.subjectKappa-Carrageenan (K-Carr)en_US
dc.subjectWound dressing with antibiotic releaseen_US
dc.titlePoly(vinyl alcohol)/(hyaluronic acid-g-kappa-carrageenan) hydrogel as antibiotic-releasing wound dressingen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Orman Mühendisliği Bölümü Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu