N-Boc-Amino Acid Mediated Morita-Baylis Hillman reaction of methylphenyl glyoxylate

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dc.contributor.authorKoz, Gamze
dc.contributor.authorCoskun, Necdet
dc.date.accessioned2026-02-08T15:08:25Z
dc.date.available2026-02-08T15:08:25Z
dc.date.issued2023
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractThe organocatalyzed Morita-Baylis Hillman (MBH) reaction of ?-keto esters is a challenging carbon-carbon bond-forming reaction. We developed a catalytic system for the MBH reaction of methylphenyl glyoxylate with methyl vinyl ketone in a polar aprotic solvent. We used N-Boc-L-pipecolinic acid as a proton transfer mediator and 4-dimethylaminopyridine as the tertiary amine catalyst. We obtained the MBH adduct with a 66% yield in 48h. We proposed a detailed reaction mechanism involving a transition state that includes the hydrogen transfer by the acid functional group of N-Boc-L-pipecolinic acid.
dc.identifier.doi10.38088/jise.1333127
dc.identifier.endpage166
dc.identifier.issn2602-4217
dc.identifier.issue2
dc.identifier.startpage160
dc.identifier.trdizinid1213613
dc.identifier.urihttps://doi.org/10.38088/jise.1333127
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5020
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of Innovative Science and Engineering (JISE)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260207
dc.subjectMorita-Baylis Hillman reaction
dc.subject?-Keto ester
dc.subjectN-Boc-L-pipecolinic acid
dc.subject4-Dimethylaminopyridine
dc.titleN-Boc-Amino Acid Mediated Morita-Baylis Hillman reaction of methylphenyl glyoxylate
dc.typeArticle

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