Semi-Purified Saponins of Holothuria poli Associated Antiproliferation in Tumor Cell Lines

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dc.authorid0000-0002-2882-6811en_US
dc.authorscopusid6505809121en_US
dc.contributor.authorMert-Ozupek, Nazli
dc.contributor.authorBasbinar, Yasemin
dc.contributor.authorUysal-Kilic, Tugba
dc.contributor.authorKoz, Ömer
dc.contributor.authorEllidokuz, Hulya
dc.contributor.authorCavas, Levent
dc.date.accessioned2022-04-21T06:45:24Z
dc.date.available2022-04-21T06:45:24Z
dc.date.issued2022en_US
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Bölümüen_US
dc.description.abstractThe incidence of cancer has exhibited an increasing trend in recent years because of many reasons such as environmental and nutritional factors. There is a great need for the development of new and natural molecules with lower side effects in the therapy of cancer. It was aimed to evaluate the antiproliferative effect of semi-purified triterpene glycosides of Holothuria poli on different human cancer cell lines. The body walls of H. poli as the main sources of saponins were used and the saponin content of the extract was characterized by MALDI-TOF/MS. The antiproliferation activity of the characterized extract was tested on cancer cell lines. The extract showed antiproliferative effect on the studied cancer cell lines. The mass analysis results reveal that Holothurin A is one of the saponins within the extract. The measured IC50 values were found as 31.41 ± 2.20, 77.45 ± 0.23, and 34.79 ± 0.90 µg mL−1 for HT-29, UPCI-SCC-131, and T84 cell lines, respectively. H. poli secretes not only specific saponins but also a cocktail of them. Specific versus. cocktails of the saponins and by also applying organic modification must be studied in further research to understand their mechanisms in the antiproliferation studies since this paper reveals promising results.en_US
dc.identifier.doi10.1080/01635581.2021.1952630en_US
dc.identifier.endpage1518
dc.identifier.issue4
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1511
dc.identifier.urihttps://hdl.handle.net/20.500.12885/1958
dc.identifier.volume74
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKoz, Ömer
dc.language.isoenen_US
dc.publisherRoutledgeen_US
dc.relation.ispartofNutrition and Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSemi-Purified Saponins of Holothuria poli Associated Antiproliferation in Tumor Cell Linesen_US
dc.typeArticleen_US

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