The metformin administration on pancreatic tissue damage in metastatic rat prostate cancer and STZ induced diabetes model

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dc.authorid0000-0002-3408-7867
dc.contributor.authorKoroglu, Pinar
dc.contributor.authorErtik, Onur
dc.contributor.authorBulan, Omur Karabulut
dc.contributor.authorYanardag, R.
dc.date.accessioned2026-02-08T15:14:57Z
dc.date.available2026-02-08T15:14:57Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractCancer is the major cause of mortality in most nations, and a severe health problem worldwide. According to epidemiological studies, diabetes shows an increased risk for a variety of cancers. Metformin is a semisynthetic biguanide produced from the French lilac plant. The effects of metformin on pancreatic tissue damage in cancer and diabetic rat models were evaluated histologically and biochemically in the present study. The diabetes model was induced in Copenhagen rats using a single dose of streptozotocin, while prostate cancer was induced through subcutaneous inoculation of MAT-LyLu cells into the animals. Metformin was administered by gavage daily after inoculation of the Mat-Lylu cells. Histological evaluation showed moderate to severe damage to the pancreas following diabetes and cancer process. Administration of metformin reversed these effects showing a beneficial effect of metformin. Metformin treatment can be considered an adjuvant candidate for pancreas tissue in diabetes, prostate cancer and cancer therapy related damage. Metformin alleviates diabetes and cancer induced pancreatic cytotoxicity by regulating oxidative stress and antioxidant capacity. More research will be needed to explore the metformin effect.
dc.identifier.doi10.1007/s10735-025-10478-4
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue4
dc.identifier.pmid40542925
dc.identifier.scopus2-s2.0-105008560168
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10735-025-10478-4
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5528
dc.identifier.volume56
dc.identifier.wosWOS:001512843800008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectSTZ diabetes
dc.subjectProstate cancer
dc.subjectMetformin
dc.subjectPancreas
dc.subjectOxidative stress
dc.titleThe metformin administration on pancreatic tissue damage in metastatic rat prostate cancer and STZ induced diabetes model
dc.typeArticle

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