Effect of akermanite powders on mechanical properties and bioactivity of chitosan-based scaffolds produced by 3D-bioprinting

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dc.authorid0000-0002-6685-5656en_US
dc.contributor.authorDuman, Şeyma
dc.contributor.authorBulut, B.
dc.date.accessioned2021-03-20T20:26:54Z
dc.date.available2021-03-20T20:26:54Z
dc.date.issued2021
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Metalurji ve Malzeme Mühendisliği Bölümüen_US
dc.description.abstractThis study reports on microstructural, mechanical, and bioactive properties of the chitosan based composite scaffolds reinforced by akermanite. Firstly, the synthesis of akermanite powders was investigated by three different methods as sol-gel, ball-milling, and spray drying, with additional heat treatments. The morphological and microstructural characterizations revealed that the akermanite powders with the homogeneous and narrow particle size distributions were successfully obtained by spray drying and following heat treatment methods. Secondly, the chitosan/akermanite composite scaffolds were produced by the combination of 3D-bioprinting and lyophilization methods. SEM analyses of produced composite scaffolds indicated the interconnected and open-pore structures. The mechanical test results showed that the increasing akermanite addition enhanced the strength of composite scaffolds significantly. The bioactivity test results presented that the composite scaffolds had good in vitro bioactivity based on their good apatite-formation abilities on their surfaces and in simulated body fluid. According to the results, the bioactive 3D-printed scaffold with improved mechanical properties promises the good potential for bone tissue engineering applications. © 2021 Elsevier Ltd and Techna Group S.r.l.en_US
dc.description.sponsorship190Y017en_US
dc.description.sponsorshipThe authors thank instructors Zeynep Ordu, Murat Eroğlu, Olcay Severgün, and research assistants Yasin Altun and Recep İlhan for their help in running the mechanical testing and SEM experiments. They also thank Bursa Technical University Central Research Laboratory for providing laboratory facilities for this research. This work was supported financially by Bursa Technical University Scientific Research Projects (project no. 190Y017 ).en_US
dc.identifier.doi10.1016/j.ceramint.2021.01.258en_US
dc.identifier.issn0272-8842
dc.identifier.scopus2-s2.0-85100429276en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1016/j.ceramint.2021.01.258
dc.identifier.urihttps://hdl.handle.net/20.500.12885/1337
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDuman, Şeyma
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofCeramics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAkermaniteen_US
dc.subjectApatite Den_US
dc.subjectBiomedical applications Een_US
dc.subjectMechanical properties Cen_US
dc.subjectPorosity Ben_US
dc.titleEffect of akermanite powders on mechanical properties and bioactivity of chitosan-based scaffolds produced by 3D-bioprintingen_US
dc.typeArticleen_US

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Metalurji ve Malzeme Mühendisliği Bölümü Yayın Koleksiyonu
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