Discovery of a Uracil-Derived Small Organic Ligand with Cytotoxic Effect on Human PC-3 Cell Lines via Apoptosis

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dc.authorid0000-0002-2882-6811
dc.authorid0000-0003-3276-1413
dc.contributor.authorPoslu, Ayse Halic
dc.contributor.authorBalaban, Rumeysa
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorErtik, Onur
dc.contributor.authorCecener, Gulsah
dc.contributor.authorKoz, Omer
dc.contributor.authorKoz, Gamze
dc.date.accessioned2026-02-08T15:14:49Z
dc.date.available2026-02-08T15:14:49Z
dc.date.issued2024
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractA series of novel 6-amino-5-salicylidene uracils (1-19) were efficiently synthesized from the condensation reaction of 5,6-diamino-1,3-dimethyluracil with substituted salicylaldehydes. The structural characterization of the compounds was performed with spectroscopic methods and elemental analysis. All compounds were evaluated for their in vitro cytotoxic activity against PC-3 (human prostate adenocarcinoma), A549 (human alveolar adenocarcinoma) and SHSY-5Y (human neuroblastoma) cancer cell lines. 3,5-di-tert-Butylsalicylaldehyde derived salicylideneuracil (6ASU-8) showed promising cytotoxic activity against PC-3 cells with an IC50 value of 1.53 +/- 1.01 mu M, compared to doxorubicin, which had an IC50 value of 3.77 +/- 1.34 mu M. 6ASU-8 induced cell cycle arrest at the G2/M phase and promoted apoptosis in PC-3 cells (p<0.05*). Molecular docking results supported the experimental data, indicating that 6ASU-8 is more effective than doxorubicin. Additionally, in silico ADME analysis revealed that 6ASU-8 possesses acceptable predictive physicochemical properties.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBIdot;TAK) [217Z221]; Bursa Technical University Scientific Research Fund [182 L14]
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUB & Idot;TAK, Grant Number 217Z221) and Bursa Technical University Scientific Research Fund (Grant Number 182 L14) are gratefully acknowledged.
dc.identifier.doi10.1002/slct.202403713
dc.identifier.issn2365-6549
dc.identifier.issue36
dc.identifier.scopus2-s2.0-85204724138
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202403713
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5458
dc.identifier.volume9
dc.identifier.wosWOS:001318769800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectUracil
dc.subjectCytotoxicity
dc.subjectPC-3
dc.subjectApoptosis
dc.subjectMolecular docking
dc.titleDiscovery of a Uracil-Derived Small Organic Ligand with Cytotoxic Effect on Human PC-3 Cell Lines via Apoptosis
dc.typeArticle

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