Curcumin-Loaded Akermanite/Chitosan/Carboxymethylcellulose Patches for Skin Wound Healing: Fabrication, Characterization, and In Vitro Cytocompatibility

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dc.authorid0000-0002-9946-6729
dc.contributor.authorMutlu, Busra
dc.contributor.authorDemirci, Fatma
dc.contributor.authorErcelik, Melis
dc.contributor.authorTekin, Cagla
dc.contributor.authorTunca, Berrin
dc.contributor.authorTerzioglu, Pinar
dc.contributor.authorDuman, Seyma
dc.date.accessioned2026-02-08T15:14:51Z
dc.date.available2026-02-08T15:14:51Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractIn this study, bioactive and biocompatible transdermal patches were fabricated through the lyophilization of a chitosan/carboxymethylcellulose/akermanite composite matrix. The influence of curcumin incorporation at 0.5%, 1%, and 2% on the physicochemical, morphological, and biological properties of the patches was systematically investigated. Scanning electron microscopy revealed an interconnected porous structure with pore sizes ranging from 29 to 57 mu m, facilitating cell infiltration and nutrient transport. Fourier transform infrared spectroscopy and energy-dispersive X-ray spectroscopy confirmed the successful integration of akermanite and curcumin, along with characteristic interactions within the polymeric network. In vitro release studies demonstrated a biphasic profile consisting of an initial burst followed by a sustained release phase, with the CCMAKCur0.5 sample achieving the highest cumulative release (94.28%). Antioxidant performance, evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, ranged from 21.55% (CCM) to 38.96% (CCMAKCur0.5), while higher curcumin concentrations reduced activity due to increased matrix densification. Simulated body fluid immersion confirmed apatite formation, particularly in CCMAKCur0.5 and CCMAKCur2, indicating enhanced bioactivity. Cytocompatibility studies with HUVECs showed no toxic effects, and scratch assays demonstrated that CCMAKCur0.5 most effectively promoted wound closure. Overall, the findings indicate that curcumin- and akermanite-loaded lyophilized patches represent promising candidates for transdermal therapeutic applications.
dc.identifier.doi10.1002/slct.202505819
dc.identifier.issn2365-6549
dc.identifier.issue47
dc.identifier.scopus2-s2.0-105024573189
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202505819
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5472
dc.identifier.volume10
dc.identifier.wosWOS:001635771500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectakermanite
dc.subjectchitosan
dc.subjectcurcumin
dc.subjectdrug delivery
dc.subjecttransdermal patches
dc.titleCurcumin-Loaded Akermanite/Chitosan/Carboxymethylcellulose Patches for Skin Wound Healing: Fabrication, Characterization, and In Vitro Cytocompatibility
dc.typeArticle

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