A Facile Method for Controlled Fabrication of Hybrid Silver Nanoparticle-Poly(epsilon-caprolactone) Fibrous Constructs with Antimicrobial Properties

Basit Öğe Kaydı
dc.contributor.authorBhullar, Sukhwinder Kaur
dc.contributor.authorGazioğlu Rüzgar, Duygu
dc.contributor.authorFortunato, Giuseppino
dc.contributor.authorAneja, Ginpreet Kaur
dc.contributor.authorOrhan, Mehmet
dc.contributor.authorSaber-Samandari, Saeed
dc.date.accessioned2021-03-20T20:12:27Z
dc.date.available2021-03-20T20:12:27Z
dc.date.issued2019
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Makine Mühendisliği Bölümüen_US
dc.description.abstractInfection is one of the major factors affecting wound healing. The use of polymeric fibrous constructs or scaffolds with encapsulated biologically active components has shown great potential in topical wound care as wound dressings to expedite wound healing process; however, there is a limitation in precise control over the release of active components. Therefore, in this study, the authors developed a facile method for controlled fabrication of poly(epsilon-caprolactone) (PCL) microfibrous constructs with silver (Ag) nanoparticles as antibacterial agent by single capillary electrospinning. By optimizing spinning parameters, the PCL microfibrous constructs were fabricated. The encapsulation of Ag nanoparticles within the PCL microfibers was confirmed using microstructural analysis. The encapsulation efficacy and release profile of Ag was evaluated in vitro. The diffusion study further revealed the controlled release and optimal bioavailability of Ag during the experimental period. In vitro assessment of antibacterial activity of electrospun hybrid constructs showed a high antibacterial activity and an inhibitory effect on the growth of both staphylococcus aureus and escherichia coli bacteria when compared to PCL and their efficiency of antibacterial activity also varied with respect to the percent of encapsulated Ag nanoparticles. This kind of Ag nanoparticles-loaded PCL microfibrous constructs may be considered for wound care applications.en_US
dc.identifier.doi10.1166/jnn.2019.16641en_US
dc.identifier.endpage6955en_US
dc.identifier.issn1533-4880
dc.identifier.issn1533-4899
dc.identifier.issue11en_US
dc.identifier.pmid31039846en_US
dc.identifier.startpage6949en_US
dc.identifier.urihttp://doi.org/10.1166/jnn.2019.16641
dc.identifier.urihttps://hdl.handle.net/20.500.12885/562
dc.identifier.volume19en_US
dc.identifier.wosWOS:000475752300010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBhullar, Sukhwinder Kaur
dc.language.isoenen_US
dc.publisherAmer Scientific Publishersen_US
dc.relation.ispartofJournal Of Nanoscience And Nanotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolymeric Constructen_US
dc.subjectSilver Nanoparticleen_US
dc.subjectElectrospinningen_US
dc.subjectAntimicrobialen_US
dc.subjectControlled Releaseen_US
dc.subjectWound Careen_US
dc.titleA Facile Method for Controlled Fabrication of Hybrid Silver Nanoparticle-Poly(epsilon-caprolactone) Fibrous Constructs with Antimicrobial Propertiesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Bhullar-2019-A-facile-method-for-controlled-fabr.pdf
Boyut:
5.35 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makine Mühendisliği Bölümü Yayın Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu