Preparation and Characterisation of Vitamin-Loaded Electrospun Nanofibres as Promising Transdermal Patches

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dc.authorid0000-0003-2048-2951en_US
dc.contributor.authorParın, Fatma Nur
dc.contributor.authorYıldırım, Kenan
dc.date.accessioned2021-03-20T20:09:13Z
dc.date.available2021-03-20T20:09:13Z
dc.date.issued2021
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Polimer Malzeme Mühendisliği Bölümüen_US
dc.description.abstractIn this study, bioactive fibres were produced using polyvinyl alcohol (PVA), gelatin, polyvinyl pyrrolidone (PVP) as a polymer matrix, and different amounts of folic acid (FA) as a vitamin using the electrospinning technique. Loading of the folic acid in the polymers was determined by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (47R-FTIR); morphologies and average diameters were analysed by Scanning Electron Microscopy (SEM), and Thermal Gravimetric Analysis (TGA) was applied to determine thermal behaviours. The FTIR spectra and TGA thermograms showed the successful incorporation of folic acid into the fibres. SEM images showed that various smooth and heterogenous electrospun fibres were produced with average diameters ranging from 125 to 980 nm. An in-vitro study was carried out using dissolved FA in an artificial sweat solution (acidic media, pH 5.44), and UV-Vis analysis of electrospun fibres was made. The in vitro release study showed that the FA loaded nanofibres had initial vitamin burst release behaviour. The maximum vitamin release percentage of the PTA/FA, gelatin/FA, and PTP/FA fibres was obtained as 86.88%, 80.2%, and 76.66%, respectively From these results, we can state that FA-loaded fibres can be potential candidates for transdermal patches and topical applications.en_US
dc.description.sponsorshipBursa Technical University Scientific Research Projects Coordination Unit (SRP Project) [190D003]en_US
dc.description.sponsorshipThis study was supported by Bursa Technical University Scientific Research Projects Coordination Unit (SRP Project No. 190D003). We would like to thank the employees of the Scientific and Technological Research Council of Turkey-Bursa Test and Analysis Laboratory (TUBITAK-BUTAL) for supporting the preparation of artificial sweat solutions.en_US
dc.identifier.doi10.5604/01.3001.0014.3148en_US
dc.identifier.endpage25en_US
dc.identifier.issn1230-3666
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage17en_US
dc.identifier.urihttp://doi.org/10.5604/01.3001.0014.3148
dc.identifier.urihttps://hdl.handle.net/20.500.12885/311
dc.identifier.volume29en_US
dc.identifier.wosWOS:000607833400003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorParın, Fatma Nur
dc.language.isoenen_US
dc.publisherInst Chemical Fibresen_US
dc.relation.ispartofFibres & Textiles In Eastern Europeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectvitamin releaseen_US
dc.subjectfolic aciden_US
dc.subjectnanofibreen_US
dc.subjectin-vitro studyen_US
dc.subjectelectrospinningen_US
dc.titlePreparation and Characterisation of Vitamin-Loaded Electrospun Nanofibres as Promising Transdermal Patchesen_US
dc.typeArticleen_US

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