Chronic Occupational Exposure to Chemical Mixtures Induces Genomic Instability in Paint Workers

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dc.authorid0000-0001-5283-9973
dc.authorid0000-0001-8581-8933
dc.authorid0000-0002-0290-1166
dc.contributor.authorIritas, Servet Birgin
dc.contributor.authorBacanli, Merve Gudul
dc.contributor.authorTaner, Gokce
dc.contributor.authorTurksoy, Vugar Ali
dc.contributor.authorTutkun, Lutfiye
dc.contributor.authorYilmaz, Omer Hinc
dc.contributor.authorBasaran, Ayse Nursen
dc.date.accessioned2026-02-08T15:16:03Z
dc.date.available2026-02-08T15:16:03Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractThis study's objective was to evaluate genotoxic effects on automotive paint workers who are exposed to a complex mixture of VOCs, heavy metals, and solvents. Biological samples, including blood, urine, and buccal epithelial cells, were collected from 80 exposed workers and 80 demographically matched control subjects. DNA damage was assessed using the alkaline COMET assay in lymphocytes and whole blood. The Buccal Micronucleus Cytome (BMCyt) assay was also employed to identify cytogenetic abnormalities. Additionally, trichloroacetic acid (TCA), hippuric acid (HA), phenol, and lead (Pb) levels were measured as biomarkers of exposure. A significant increase in DNA damage was observed in the lymphocytes and whole blood of exposed workers (p < 0.05) BMCyt analysis also revealed higher frequencies of micronuclei (MN), binucleated cells, condensed chromatin (CC), and karyorrhectic (KHC) and pyknotic cells (PYC) in buccal cells (p < 0.05). Elevated levels of urinary HA, phenol, TCA, and blood lead indicated systemic chemical exposure. DNA damage positively correlated with these biomarkers, supporting a strong link between chronic occupational exposure and genotoxicity. The findings from this study highlight the critical importance of implementing effective safety measures and consistent biomonitoring for paint workers to prevent adverse health effects.
dc.identifier.doi10.3390/toxics13090785
dc.identifier.issn2305-6304
dc.identifier.issue9
dc.identifier.pmid41012406
dc.identifier.scopus2-s2.0-105017457999
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/toxics13090785
dc.identifier.urihttps://hdl.handle.net/20.500.12885/6093
dc.identifier.volume13
dc.identifier.wosWOS:001581327100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofToxics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWOS_KA_20260207
dc.subjectpaint workers
dc.subjectoccupational exposure
dc.subjectDNA damage
dc.subjectcomet assay
dc.subjectbuccal micronucleus assay
dc.subjecttrichloroacetic acid
dc.subjecthippuric acid
dc.subjectphenol
dc.subjectlead
dc.titleChronic Occupational Exposure to Chemical Mixtures Induces Genomic Instability in Paint Workers
dc.typeArticle

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