Assessing the effects of boron-doped biphasic calcium phosphate on the characteristics of chitosan-based composite foams

Basit Öğe Kaydı
dc.authorid0000-0002-9946-6729
dc.authorid0000-0002-6685-5656
dc.authorid0000-0002-4037-626X
dc.contributor.authorAcar, Nurcan
dc.contributor.authorMutlu, Busra
dc.contributor.authorAkben, Hatice Kubra
dc.contributor.authorDuman, Seyma
dc.date.accessioned2026-02-08T15:14:58Z
dc.date.available2026-02-08T15:14:58Z
dc.date.issued2025
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractIn this study, composite foams containing chitosan (CHI) and boron doped-biphasic calcium phosphate (BCP) were developed using freeze-drying method. The quantities of BCP incorporated into the CHI matrix were introduced into the foams at three different ratios: 25 wt%, 50 wt%, and 75 wt%. The objective of this study was to investigate the microstructure, swelling, mechanical, and biological properties of boron-doped BCP/CHI-based composites. Scanning electron microscopy (SEM) micrographs revealed that all of the composites exhibited open and interconnected pore morphologies. The FTIR spectra demonstrated that boron doping interacts with the hydroxyl and phosphate groups in the CHI/BCP composites, which is evidenced by changes in peak intensities. It was found that low amounts of boron positively affected the compressive strength and in vitro cytotoxicity of the composites. Following simulated body fluid treatment, the boron-doped BCP/CHI composites exhibited robust apatite layer formation. These results indicated that the composite foams with modified physical and mechanical characteristics show considerable promise for use as composite materials in biomedical applications, including bone scaffolds or wound dressings.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBIdot;TAK) [1919B012001109]
dc.description.sponsorshipThe authors thank Professor Dr. Berrin Tunca, Dr. Melis Ercelik and Ca & gbreve;la Tekin of Uluda & gbreve; University, Department of Medical Biology for performing the cytotoxicity tests. They also thank Bursa Technical University Central Research Laboratory for providing laboratory facilities for this research. This study was financially supported by Scientific and Technological Research Council of Turkey (TUB & Idot;TAK) 2209-A-Research Project Support Programme for Undergraduate Students (Project No. 1919B012001109).
dc.identifier.doi10.1007/s10934-024-01709-2
dc.identifier.endpage496
dc.identifier.issn1380-2224
dc.identifier.issn1573-4854
dc.identifier.issue2
dc.identifier.scopus2-s2.0-105002931181
dc.identifier.scopusqualityQ1
dc.identifier.startpage485
dc.identifier.urihttps://doi.org/10.1007/s10934-024-01709-2
dc.identifier.urihttps://hdl.handle.net/20.500.12885/5535
dc.identifier.volume32
dc.identifier.wosWOS:001358217600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Porous Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWOS_KA_20260207
dc.subjectBoron
dc.subjectBiphasic calcium phosphate
dc.subjectChitosan
dc.subjectFreeze-drying
dc.subjectBiomedical applications
dc.titleAssessing the effects of boron-doped biphasic calcium phosphate on the characteristics of chitosan-based composite foams
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu