Nanophytosomes as a protection system to improve the gastrointestinal stability and bioavailability of phycocyanin

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dc.authorid0000-0002-7047-387X
dc.authorid0000-0003-0665-8041
dc.authorid0000-0002-6777-273X
dc.authorid0000-0003-2084-7076
dc.authorid0000-0003-1173-5793
dc.authorid0000-0003-2225-7993
dc.contributor.authorSahin, Oya Irmak
dc.contributor.authorDundar, Ayse Neslihan
dc.contributor.authorOzdemir, Sebahat
dc.contributor.authorUzuner, Kubra
dc.contributor.authorParlak, Mahmud Ekrem
dc.contributor.authorDagdelen, Adnan Fatih
dc.contributor.authorSaricaoglu, Furkan Turker
dc.date.accessioned2026-02-12T21:05:30Z
dc.date.available2026-02-12T21:05:30Z
dc.date.issued2022
dc.departmentBursa Teknik Üniversitesi
dc.description.abstractNano-phytosomes (NP), lipid-based nano-carriers, were used to encapsulate the phycocyanin. Phycocyanin (Phy) is known for its important biological properties with low bioavailability and low stability. The aim of the study was to prepare phosphatidylcholine (PC) based Phy loaded NP to overcome the bioavailability and storage stability issues. The characterization of NP such as entrapment efficiency (EE), particle size, poly-dispersity index (PDI), zeta-potential and microstructural properties was conducted and in vitro bioaccessibility and storage stability of bioactive properties were investigated. The highest EE was determined as 81.92% however with a loading capacity (LC) of 58.12%. Phy-NPs showed good characteristics, such as low PDI values (<0.5), low particle size (106.13-134.10 nm), and non-dense spherical shape of microstructure. All NP complexes showed significant bioaccessibility with total phenolic content (TPC) values greater than 50% in intestinal tract. Unfortunately, PC based NP did not show a clear-cut pattern of TPC and color protection of Phy via increased PC content.
dc.identifier.doi10.1016/j.fbio.2022.102052
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85138811380
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2022.102052
dc.identifier.urihttps://hdl.handle.net/20.500.12885/6990
dc.identifier.volume50
dc.identifier.wosWOS:000876035100002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofFood Bioscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260212
dc.subjectPhycocyanin
dc.subjectPhytosome
dc.subjectPhytochemical
dc.subjectNanocarrier
dc.subjectStability
dc.subjectIn vitro bioaccessibility
dc.titleNanophytosomes as a protection system to improve the gastrointestinal stability and bioavailability of phycocyanin
dc.typeArticle

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