Co-electrospun-electrosprayed PVA/folic acid nanofibers for transdermal drug delivery: Preparation, characterization, and in vitro cytocompatibility

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dc.authorid0000-0003-2048-2951en_US
dc.contributor.authorParın, Fatma Nur
dc.contributor.authorAydemir, Ç.İ.
dc.contributor.authorTaner, Gökçe
dc.contributor.authorYıldırım, Kenan
dc.date.accessioned2021-03-20T20:26:53Z
dc.date.available2021-03-20T20:26:53Z
dc.date.issued2021
dc.departmentBTÜ, Mühendislik ve Doğa Bilimleri Fakültesi, Polimer Malzeme Mühendisliği Bölümüen_US
dc.description.abstractIn this study, hydrophilic based bioactive nanofibers were produced via an electrospinning and electrospraying simultaneous process. Poly(vinyl alcohol) (PVA), poly(vinyl alcohol)-gelatin (PVA-Gel), and poly(vinyl alcohol)-alginate (PVA-Alg) polymers were used as the matrix material and folic acid (FA) particles were dispersed simultaneously on the surface of the nanofibers. The morphology of the nanofibers (NFs) was uniform and confirmed by scanning electron microscopy. Thermal behavior, chemical structure of the composite nanofibers were investigated by thermogravimetric analysis, and Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy which showed that no chemical bonding between vitamin and polymers. A fast release of FA-loaded electrospun fibers was carried out by UV-Vis in vitro study within the 8 hour-period in artificial sweat solutions (pH 5.44). The obtained PVA/FA, PVA-Gel/FA, and PVA-Alg/FA fibers released 49.6%, 69.55%, and 50.88% of the sprayed FA in 8 h, indicating the influence of polymer matrix and polymer-drug interactions, on its release from the polymer matrix. Moreover, biocompatibility of all developed novel NFs was assessed by two different cytotoxicity tests, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and neutral red uptake (NRU) assay in L929 (mouse fibroblasts) cell lines. In all cases, it is concluded that these new electrospun fibers had fast-release of the vitamin and the hybrid process is suitable for transdermal patch applications, especially for skin-care products. The results of cytocompatibility assays on L929 reveal that all prepared NFs have no or slight cell toxicity. PVA and PVA-Gel with/without FA nanofibers seems more biocompatible than PVA-Alg nanofibers. © The Author(s) 2021.en_US
dc.description.sponsorship190D003en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Bursa Technical University Scientific Research Projects Coordination Unit (SRP Project No. 190D003). We would like to thank the employees of the Scientific and Technological Research Council of Turkey- Bursa Test and Analysis Laboratory (TUBİTAK-BUTAL) for supporting the preparation of artificial sweat solutions and thank to İbrahim ŞEN (Central Research Laboratory, Bursa Technical University) for his help in TGA analysis.en_US
dc.identifier.doi10.1177/1528083721997185en_US
dc.identifier.issn1528-0837
dc.identifier.scopus2-s2.0-85102256375en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1177/1528083721997185
dc.identifier.urihttps://hdl.handle.net/20.500.12885/1323
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorParın, Fatma Nur
dc.language.isoenen_US
dc.publisherSAGE Publications Ltden_US
dc.relation.ispartofJournal of Industrial Textilesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytotoxicityen_US
dc.subjectDrug releaseen_US
dc.subjectelectrospinningen_US
dc.subjectelectrosprayingen_US
dc.subjectfolic aciden_US
dc.subjectnanofiberen_US
dc.titleCo-electrospun-electrosprayed PVA/folic acid nanofibers for transdermal drug delivery: Preparation, characterization, and in vitro cytocompatibilityen_US
dc.typeArticleen_US

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